宫颈癌患者岩藻糖基转移酶4的表达特点及与介入治疗预后的关系

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Abstract Objective To investigate the clinical significance of expression of fucoidyltransferase 4 (FUT4) in cervical cancer and its relationship with prognosis after interventional therapy. Methods Seventy-four cases of cervical cancer (cervical cancer group) in Hu′nan Maternal and Child Health Care Hospital from February 2012 to February 2017 were selected and treated with interventional therapy combined with hysterectomy, and 40 cases of hysterectomy with hysteromyoma were selected as control (control group), the expression of FUT4 protein was detected by Western blot, and the prognosis of patients was followed up. Results The relative expression of FUT4 protein in cervical cancer cervical cancer group was significantly higher than that in the control group (P < 0.05). The relative expression of FUT protein in patients with tumor diameter > 4 cm and lymph node metastasis were significantly higher than the tumor diameter ≤ 4 cm and no lymph node metastases (P < 0.05). The median duration of disease free progression and the total survival time in down regulation of FUT protein expression patients were higher than those in patients with the invariant and up-regulated expression of FUT protein (P < 0.05). Conclusion FUT4 protein is highly expressed in cervical cancer patients, which is related to the clinicopathological characteristics of patients. Patients with down-regulation of FUT4 protein after interventional therapy has a good prognosis.

Key words： Fucoidyltransferase 4 Cervical cancer Interventional therapy Prognosis

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	HU Rui WANG Yinxia YANG Guanghui LI Qingchun HUANG Ting TANG Shenwei

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HU Rui WANG Yinxia YANG Guanghui LI Qingchun HUANG Ting TANG Shenwei. Expression of fucoidyltransferase 4 in cervical cancer and its relationship with prognosis after interventional therapy[J]. 中国医药导报, 2019, 16(26): 89-92.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I26/89

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