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| Application of trigeminal somatosensory evoked potentials in early diagnosis of blepharospasm |
| ZHANG Ting JIANG Lijie LIU Xiaoyang YU Min |
| Department of Neurology, the Third People′s Hospital of Dalian, Liaoning Province, Dalian 116000, China |
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Abstract Objective To investigate the value of trigeminal somatosensory evoked potential (TSEP) in the early diagnosis of blepharospasm. Methods From November 2016 to June 2017, 73 cases with early non-spasmodic symptoms of blepharospasm admitted to the Third People's Hospital of Dalian were selected and 30 cases of healthy people as group Ⅱ and groupⅠ respectively. According to the testing results of TSEP, patients of group Ⅱ were further divided into two subgroups, 40 cases (group Ⅱa) with abnormal TSEP and 33 cases (group Ⅱb) with the normal TSEP. The peak-to-peak amplitude of N13-P19, P19-N30, N13/P19 and P19/N30 at locus C (5,6), F (5,6) peak-to-peak amplitude at sites N13′-P19′, P19′- N30′, N13′/P19′ /N30′ in each group were statistically analyzed. One year of follow-up, the incidence of blepharospasm group Ⅱa and group Ⅱb were observed. Results Compared with group Ⅰ, P19/N30 peak-to-peak amplitude and P19′/N30′ peak-to-peak amplitude of goup Ⅱ were increased, the differences were statistically significant (P ＜ 0.05), the other indicators showed no statistically significant difference (P ＞ 0.05). Compared with group Ⅱb, P19/N30 peak-to-peak amplitude and P19′/ N30′ peak-to-peak amplitude of group Ⅱa were increased, the differences were highly statistically significant (P ＜ 0.01), the other indicators showed no statistically significant difference (P ＞ 0.05). One year of follow-up, the incidence of blepharospasm of groupⅡa was higher than group Ⅱb, the difference was statistically significant (P ＜ 0.05). Conclusion TSEP can detect increased excitability of nerve nucleus group in the early stage of blepharospasm, providing basis for early diagnosis of blepharospasm, and can be popularized in clinical work.
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