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| Effect of Erchen Decoction combined with Taohong Siwu Decoction in treating hemorrhagic apoplexy caused by phlegm and blood stasis in convalescence |
| LI Hui LI Hongni TANG Sen CHEN Bo ZHAO Dingya FU Chengbao▲ |
| The Fifth Department of Encephalopathy, Xi′an Encephalopathy Hospital of Traditional Chinese Medicine, Shaanxi Province, Xi′an 710032, China |
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Abstract Objective To investigate the effect of Erchen Decoction and Taohong Siwu Decoction in treating hemorrhagic apoplexy caused by phlegm and blood stasis in convalescence. Methods From January 2014 to December 2017, 90 cases of hemorrhagic stroke convalescence patients admitted to Xi′an Encephalopathy Hospital of Traditional Chinese Medicine were selected. Patients were divided into control group (n = 45) and treatment group (n = 45) according to the random number table method. The control group received conventional treatment, the treatment group was treated with Erchen Decoction and Taohong Siwu Decoction on the basis of the control group. The two groups received continuous treatment for 28 days. The clinical efficacy of the two groups was evaluated. TCM syndrome score and Glasgow proghostic scale (GOS) score were measured before and after treatment, meanwhile, serum levels of hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4) were measured before and after treatment and the incidence of adverse reactions in the two groups was observed. Results The clinical effective rate of the treatment group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, TCM syndrome score and serum hs-CRP, TNF-α and IL-4 levels in the treatment group were significantly lower than those in the control group (all P ＜ 0.05); GOS scores were significantly higher than those of the control group, with statistically significant differences (P ＜ 0.05). During the treatment, there was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Erchen Decoction and Taohong Siwu Decoction has significant clinical effect in treating patients with phlegm and blood stasis blocking collaterals syndrome of hemorrhagic stroke during recovery, which can significantly improve clinical symptoms and reduce serum inflammatory factor level, and has good safety.
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