入院时静息心率与慢性心力衰竭患者血清炎性因子及脑钠肽的关系

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Abstract Objective To investigate relationship between resting heart rate at admission and serum inflammatory factors and brain natriuretic peptide (BNP) in patients with chronic heart failure (CHF). Methods One hundred and fifty-three cases of CHF treated in Beijing Ditan Hospital, Capital Medical University from May 2013 to February 2018 were selected as subjects of study. According to the different resting heart rates at admission, patients were divided into three groups: group A, group B and group C. Group A (resting heart rate ≤70 beats/min) was 46 cases, group B (resting heart rate ＞70-＜90 beats/min) was 52 cases and group C (resting heart rate ≥90 beats/min) was 55 cases. The resting heart rate, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and left ventricular ejection fraction (LVEF) were measured under resting condition after the patients were admitted and had 1 hour rest. Fasting venous blood was collected on the next day after admission. Serum levels of C-reactive protein (CRP), BNP, interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α were measured. Pearson correlation between resting heart rate at admission and serum inflammatory factors and BNP in patients was analyzed. Results The contents of CRP, BNP, IL-1β, IL-6 and TNF-α in group C were significantly higher than those in group A and B (P < 0.05), and the contents of the above indexes in group B were significantly higher than those in group A (P < 0.05). LVEDD and LVESD in group C were significantly longer than those in group A and B, and LVEF in group C was significantly lower than those in group A and B (P < 0.05); LVEDD and LVESD in group B were significantly longer than those in group A, and LVEF in group B was significantly lower than that in group A (P < 0.05). The number of NYHA class Ⅱ cases in group C was significantly less than that in group A and B, and the number of NYHA class Ⅲ/Ⅳ cases in group C was significantly more than those in group A and B (P < 0.05). Resting heart rate of CHF patients at admission was positively correlated with CRP, BNP, IL-1β, IL-6, TNF-α, LVEDD and LVESD (r = 0.350, 0.584, 0.305, 0.411, 0.349, 0.334, 0.395, all P < 0.05), and resting heart rate of CHF patients at admission was negatively correlated with LVEF (r = -0.425, P < 0.05). Conclusion The resting heart rate at admission is positively correlated with CRP, IL-1β, IL-6, TNF-α inflammatory factors and serum BNP levels in CHF patients, and is correlated with cardiac function.

Key words： Resting heart rate Chronic heart failure Inflammatory factor Brain natriuretic peptide

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	LV Xueya LIU Haiyan ZHENG Di HAN Xiaotao DONG Xi

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LV Xueya LIU Haiyan ZHENG Di HAN Xiaotao DONG Xi. Relationship between resting heart rate at admission and serum inflammatory factors and brain natriuretic peptide in patients with chronic heart failure[J]. 中国医药导报, 2019, 16(26): 70-73.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I26/70

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