小胶质细胞在脑缺血再灌注损伤中的作用

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Abstract Neuroinflammatory reaction plays an important role in the pathophysiology of cerebral ischemia-reperfusion injury. Microglia is an important immune effector cell in the central nervous system (CNS), and it is the first defensive line for CNS. Microglia can release a variety of inflammatory factors and a variety of growth factors and increase the expression of various proinflammatory enzymes. It plays a key role in the neuroinflammatory reactions. During cerebral ischemia-reperfusion injury occurs, microglia cells are activated by a variety of cytokines at“rest”, such as γ-interferon, tumor cytokine-α, colony stimulating factor, transforming growth factor, etc. Then it transforms into different phenotypes of “activated” microglia, namely M1 and M2 type. They play a dual effect of anti-inflammatory and pro-inflammatory, and affect the occurrence and development of cerebral ischemia-reperfusion injury. This review describes the physiological characteristics of microglia, factors affecting microglia activation, phenotypic transformation characteristics of microglia and factors regulating phenotypic changes, in order to understand the role of microglia in cerebral ischemia reperfusion injury, and characteristics of activation and phenotypic transformation. It provides the basis for the prevention, treatment and prognosis of cerebral ischemia-reperfusion injury.

Key words： Microglia Activation Neuro-inflammation Ischemia reperfusion

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	Articles by authors
	QI Ya′nan1
	2 GUO Dazhi2 PAN Shuyi1
	2

Cite this article:

QI Ya′nan1,2 GUO Dazhi2 PAN Shuyi1,2. The role of microglia cells in cerebral ischemia reperfusion injury[J]. 中国医药导报, 2019, 16(26): 26-28,53.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I26/26

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