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| Clinical effect of self-made Wenwei Sanhan Decoction in the treatment of chronic atrophic gastritis with spleen-stomach deficiency and cold type |
| MA Runxing1 MA Yushou2 |
1.Department of Traditional Chinese Medicine, Qinghai Transportation Hospital, Qinghai Province, Xi′ning 810001, China;
2.Department of Traditional Chinese Medicine, the First People′s Hospital of Huangzhong County of Qinghai Province, Qinghai Province, Huangzhong 810000, China |
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Abstract Objective To explore clinical effect of self-made Wenwei Sanhan Decoction in the treatment of chronic atrophic gastritis (CAG) with spleen-stomach deficiency and cold type. Methods One hundred and three CAG patients with spleen-stomach deficiency and cold type admitted to Qinghai Transportation Hospital from March 2016 to August 2018 were selected, they were divided into control group (n = 51) and study group (n = 52) according to the random number table method. Control group was treated with Qiwei Weitong Capsules and study group was treated with Wenwei Sanhan Decoction on the basis of control group. Clinical effect, clinical symptom score and thromboxane B2 (TXB2), pepsinogen (PG) were compared between two groups. Incidence of adverse reactions during the treatment in two groups was observed. Results After treatment of 8 weeks, total effective rate of study group was significantly higher than that of control group, there was a significant difference (P < 0.05). After treatment of 8 weeks, scores of clinical symptoms such as dry mouth and bitter mouth, fullness of upper abdomen, fatigue, poor appetite, dyspepsia in both groups were lower than those before treatment, and those in study group were lower than those in control group (P < 0.05). After treatment of 8 weeks, plasma TXB2 level of two groups was lower than that before treatment, and level of TXB2 in study group was lower than that in control group (P < 0.05). After treatment of 8 weeks, level of plasma PGⅠ in two groups was higher than that before treatment, and that in study group was higher than that in control group (P < 0.05). There was no significant difference in plasma PGⅡ level between two groups before treatment and after treatment of 8 weeks (P > 0.05). There was no significant difference in incidence rate of adverse reaction between two groups during treatment (P > 0.05). Conclusion Self-made Wenwei Sanhan Decoction is effective in the treatment of CAG with spleen-stomach deficiency and cold type. It can effectively improve clinical symptoms of patients and the levels of TXB2 and PG in serum without increasing the incidence rate of adverse reaction. It has high clinical value.
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[1] Tong Y，Wu Y，Song Z，et al. The potential value of serum pepsinogen for the diagnosis of atrophic gastritis among the health check-up populations in China：a diagnostic clinical research [J]. BMC Gastroenterol，2017，17（1）：88.
[2] Majka J，Wierdak M，Brzozowska I，et al. Melatonin in prevention of the sequence from reflux esophagitis to barrett′s esophagus and esophageal adenocarcinoma：experimental and clinical perspectives [J]. Int J Mol Sci，2018，19（7）：2033.
[3] Takeoka A，Tayama J，Yamasaki H，et al. Impact of Helicobacter pylori immunoglobuling levels and atrophic gastritis status on risk of metabolic syndrome [J]. PLoS One，2016，11（11）：e0166588.
[4] 杨晋翔，安静，彭继升，等.半夏泻心汤加减方治疗慢性萎缩性胃炎临床疗效的系统评价[J].北京中医药大学学报，2015，38（1）：46-52.
[5] 魏玮，杨洋.慢性萎缩性胃炎诊治现状及中医药治疗优势[J].中医杂志，2016，57（1）：36-40.
[6] 中华医学会消化病学分会.中国慢性胃炎共识意见（上）（2006，上海）[J].中华消化杂志，2007，27（1）：45-49.
[7] 郑筱萸.中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002：352-354.
[8] 张声生，李乾构，唐旭东，等.慢性萎缩性胃炎中医诊疗共识意见[J].中医杂志，2010，51（8）：749-753.
[9] 李国锐.《中医病症诊断疗效标准》出台[J].质量技术监督研究，1995（2）：5.
[10] 马银平，靳秀芳，徐凤超，等.乌梅丸联合三联疗法治疗慢性萎缩性胃炎临床研究[J].国际中医中药杂志，2018， 40（8）：702-705.
[11] 孔春雨，吴梅，李昭咏，等.叶酸联合气滞胃痛颗粒对Hp阳性慢性萎缩性胃炎患者血清胃泌素、sIL-2R及免疫功能影响[J].中国生化药物杂志，2015，36（7）：101-103.
[12] 庄瑛瑛，饶紫兰，房太勇，等.瑞巴派特片联合雷贝拉唑钠肠溶片治疗慢性萎缩性胃炎的临床研究[J].中国临床药理学杂志，2018，34（19）：2273-2275.
[13] 张淼，杨沈秋，孙兴华，等.参芪健胃颗粒治疗慢性萎缩性胃炎的临床研究[J].中国临床药理学杂志，2016，32（16）：1460-1463.
[14] 王丽华，马华.调气温中方治疗慢性萎缩性胃炎（脾胃虚寒型）临床观察[J].临床医药实践，2016，25（4）：271-273.
[15] 武德顺，高智深.针药结合治疗66例脾胃虚寒型胃脘痛的临床观察[J].中国处方药，2016，14（5）：90-91.
[16] 沈晓东，沈双宏.温中健脾法防治高寒地区脾胃虚寒型慢性萎缩性胃炎[J].中国医药导报，2012，9（5）：108-109.
[17] 黎友隆.健脾通络汤治疗脾胃虚弱型慢性萎缩性胃炎的效果研究[J].中国医药科学，2017，7（11）：56-58.
[18] 谢妲.荆花胃康胶丸联合摩罗丹治疗老年慢性萎缩性胃炎伴Hp感染临床疗效及对胃镜组织学的影响[J].河北医学，2017，23（3）：412-415.
[19] 李省玉.健脾消萎汤治疗脾胃虚寒型慢性萎缩性胃炎的临床观察[J].光明中医，2018，33（11）：1603-1604.
[20] 王文菊，林丹，李彩娟，等.阿莫西林联合果胶铋治疗慢性萎缩性胃炎的疗效观察[J].现代消化及介入诊疗，2016，21（1）：142-144.
[21] 魏玮，杨洋.慢性萎缩性胃炎诊治现状及中医药治疗优势[J].中医杂志，2016，57（1）：36-40.
[22] 薛双凯.论中医治疗脾胃虚寒型慢性萎缩性胃炎[J].中国处方药，2016，14（11）：98-99. |
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