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| Effect of preinjection of Nalbuphine on Etomidate - induced myoclonus during induction of general anesthesia |
| REN Yifeng1 SHI Wei2 CHEN Chengzhe1 LI Huifang1 NIU Chenguang1 ZHENG Xiaozhen1 |
1.Department of Anesthesiology, the First Affiliated Hospital of He′nan University, He′nan Province, Kaifeng 475001, China;
2.Department of Anesthesiology, West China Hospital of Sichuan University, Sichuan Province, Chengdu 610041, China |
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Abstract Objective To evaluate the effect of preinjection of Nalbuphine on Etomidate - induced myoclonus during induction of general anesthesia. Methods Sixty-four adult patients selected from the First Affiliated Hospital of He′nan University for Urological Surgery under general anesthesia from June to September 2018 were selected. The American society of anesthesiologists class Ⅰ -Ⅱ (ASA), age range from 30 to 63. Random number table method was used to divide into Nalbuphine group (N group) and control group (C group), 32 cases of each group. Before anesthesia induction, N group received 0.2 mg/kg Nalbuphine 10 mL, C group received an equal amount of normal saline, and after 150 s, both groups received 0.3 mg/kg Etomidate. The mean arterial pressure (MAP), heart rate (HR) and oxygen saturation (SpO2) of the two groups were recorded immediately before pretreatment (T0), 1 min after pretreatment (T1), immediately before Etomidate administration (T2) and 2 min after Etomidate administration (T3). Myoclonic condition within 2 min after Etomidate administration was recorded and its severity was assessed. Adverse reactions such as nausea and vomiting bradycardia and hypotension before Etomidate administration were recorded. Results Only 3 cases (9.4%) of mild myoclonus in N group, while in group C, 23 cases (71.9%) had myoclonus of varying degrees, among them, 14 cases (43.8%) were mild, 8 cases (25%) of moderate and 1 case (3.1%) of severe. The incidence of myoclonus in N group was significantly lower than that in C group (P ＜ 0.01). Comparison of MAP, HR and SpO2 at different time points in the two groups showed no statistically significant difference (P ＞ 0.05). During the induction of general anesthesia, the incidence of adverse reactions such as nausea, vomiting, bradycardia and hypotension in the two groups showed no statistically significant difference (all P ＞ 0.05). Conclusion Preinjection of 0.2 mg/kg of Nalbuphine 150 s before intravenous Etomidate injection can effectively inhibit the development of Etomidate induced myoclonus during the induction of general anesthesia.
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