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| Effect of intermuscular fat content in soleus on mortality rate of COPD patients |
| ZHANG Bin1 LI Jiaojiao1 CUI Guoqing1 CHEN Jing1 ZHANG Zhihua2 |
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Abstract Objective To investigate the effect of intermuscular fat content in soleus on the mortality rate of patients with chronic obstructive pulmonary disease (COPD). Methods One hundred and twelve non-hospitalized COPD patients diagnosed in the First Affiliated Hospital of Hebei North University from January 2014 to March 2015 were collected. Ntermuscular fat content, body mass index (BMI) and other relevant clinical data were collected and followed up by telephone for 3 years. Cox proportional hazard regression model was used to evaluate the relationship between all-cause mortality and BMI, intermuscular fat content of soleus muscle and other factors. Results A total of 21 patients died during the follow-up period, with older age and longer course of disease, COPD global initiative interpretation(GOLD) grade and intermuscular fat content in soleus muscle, and lower BMI and forced expiratory volume at 1 second (FEV1), and more patients with comorbidities, less patients receiving long-term home oxygen therapy. BMI ＜ 21 kg/m2 was a risk factor for high mortality among patients with COPD in risk model Ⅰ(HR = 2.97, P = 0.02); the soleus muscle fat content ＞ 12% was a risk factor for high mortality among patients with COPD in risk model Ⅱ(HR = 2.17, P = 0.0014). - 2 times of the logarithmic likelihood function value of risk model Ⅱ was lower than the risk modelⅠ. Conclusion BMI and intermuscular fat content of soleus have important reference value in determining the prognosis of patients with COPD at stable stage, and the latter may be superior to the former.
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