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| Research progress on the regulatory mechanism of pro-mitochondrial fusion mitotic proteins in mitochondrial fusion, division and apoptosis |
| ZHOU Manli1 WANG Jianzhang1,2 FENG Yu1 YU Yunfeng1 LIU Haochen1 JIAN Weixiong1,3 |
1.College of Traditional Chinese Medicine, Hu′nan University of Chinese Medicine, Hu′nan Province, Changsha 410208, China;
2.Department of Cardiovascular, the First Affiliated Hospital of Hu′nan University of Chinese Medicine, Hu′nan Province, Changsha 410007, China;
3.Diagnostics of Traditional Chinese Medicine, National Key Discipline, Hu′nan University of Chinese Medicine Hu′nan Provincial Key Laboratory, Hu′nan Province, Changsha 410208, China |
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Abstract Mitochondria is widely found in higher animals and plants due to their specific structure and function. Mitochondria contains a large number of enzyme systems, which can be coupled to oxidative phosphorylation via an electron transport chain to form adenosine triphosphate, which is the main production structure. The realization of mitochondrial function is inseparable from the changes in its structure. Mitochondrial fusion and division are the basis for achieving function. Mitochondrial fusion can promote the connection between adjacent mitochondria, and mitochondrial division can promote the normal distribution of mitochondria in cells, which is of great significance for maintaining normal physiological activities of the body. So far, mitochondrial fusion proteins that have been extensively studied in mammals include mitofusin 1 and mitochondrial fusion protein 2. Mitochondrial proteins include dynamin-related protein 1. The mitochondrial network structure is destroyed when the mitochondrial fusion and division movements are unbalanced, the pro-apoptotic factors such as cytochrome C are released, which leads to apoptosis. In this paper, a brief review of the regulation of mitochondrial fusion, mitochondrial fission and apoptosis was made in combination with the research results.
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