早期连续性肾脏替代治疗严重脓毒症患者的效果研究

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Abstract Objective To explore the curative effect of early continuous renal replace therapy (CRRT) for severe sepsis patients. Methods 100 cases of severe sepsis patients were chosen in ICU Department of Central Hospital of Chancheng District in Foshan City from September 2014 to September 2016, and these patients were divided into the control group and treatment group retrospectively, each group had 50 cases. The control group was given conventional treatment, and the treatment group was given early CRRT (within 6 hours of diagnosis) on the basis of the control group. The indexes of inflammatory factors, immunization and prognosis (APACHEⅡ score, SOFA score and oxygenation index) were compared between the two groups. Results After 7 days treatment, the level of CRP in the treatment group was lower than that in the control group (P < 0.05), but the levels of CD4+/CD8+ and IgA in the treatment group were higher than those in the control group (P < 0.05). The scores of APACHⅡ and SOFA in the treatment group were lower than those in the control group (P < 0.05), but oxygenation index was higher than that in the control group (P < 0.05). Conclusion Severe sepsis patients treated by early CRRT, not only can eliminate over-expressed inflammatory mediators, improve T cell function and immune function disorder, but also improve prognosis of sepsis. It is worthy of clincal application.

Key words： Sepsis Continuous renal replace therapy Immunological function Curative effect of treatment

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	WU Xiaodi CHEN Yubing WU Xiang HUANG Xiangling

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WU Xiaodi CHEN Yubing WU Xiang HUANG Xiangling. Curative effect study on early continuous renal replace therapy for severe sepsis patients[J]. 中国医药导报, 2017, 14(14): 99-102.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I14/99

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