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| Clinical effect of 5-Fluorouracil and Gemcitabine combined with concurrent radiotherapy in the treatment of locally advanced pancreatic carcinoma |
| YE Shifu CHEN Yang SHOU Feng LIN Yuanhong YE Ling |
| Department of Oncology, Jianyang People's Hospital, Sichuan Province, Jianyang 641400, China
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Abstract Objective To investigate the clinical effect of 5-Fluorouracil and Gemcitabine combined with concurrent radiotherapy in the treatment of locally advanced pancreatic carcinoma. Methods The clinical data of 80 cases of patients with locally advanced pancreatic carcinoma admitted to Jianyang People's Hospital from February 2012 to March 2016 was analyzed retrospectively, they were divided into two groups by different treatment methods, treatment group A (Gemcitabine treatment) had 30 cases, treatment group B (5-Fluorouracil, Gemcitabine treatment) had 50 cases. The physical inventory score, pain index score, general well-being assessment scale, Spitzer life quality index score of two groups before and after treatment were observed, the remission rate of clinical treatment between the two groups was compared. Results The physical inventory score, pain index score of two groups after treatment were lower than those before treatment, the general well-being assessment scale score, Spitzer quality of life index score were higher than those before treatment, the differences were all statistically significant (P ＜ 0.05). After treatment, the physical inventory score and pain index score of treatment group B were lower than those of treatment group A, the general well-being assessment scale score and Spitzer quality of life index score were higher than those of treatment group A, the differences were all statistically significant (P ＜ 0.05). The remission rate of treatment group B was higher than that of treatment group A, the difference was statistically significant (P ＜ 0.05). Conclusion 5-Fluorouracil and Gemcitabine combined with concurrent radiotherapy in the treatment of locally advanced pancreatic carcinoma can improve the patients' physical inventory, quality of life, decrease the pain degree, increase general well-being assessment and clinical effect, which is worthy of promotion and application.
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