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| Protective effect of Propofol combined with Benazepril on myocardial ischemia-reperfusion injury in patients undergoing coronary artery bypass grafting under cardiopulmonary bypass |
| LIU Zhifang XIA Yu PAN Bo ZHU Xiongkai |
| Department of Cardiac Surgery, Zhejiang Greentown Cardiovascular Hospital, Zhejiang Province, Hangzhou 310012, China |
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Abstract Objective To investigate the protective effect of Propofol combined with Benazepril pretreatment on myocardial ischemia-reperfusion injury in patients undergoing coronary artery bypass grafting under cardiopulmonary bypass. Methods From September 2014 to October 2016, 94 patients underwent coronary artery bypass grafting were divided into two groups according to random number table: observation group (47 cases), Benazepril oral before surgery 1 week, intraoperative Propofol anesthesia was continuously taken; control group (47 cases), intraoperative Propofol was taken. The levels of cTnI, CK-MB activity, sICAM-1 level and the number of patients with positive inotropic drugs were observed in two groups were observed. The incidence of adverse events, auto-resuscitation and left ventricular ejection fraction in two groups were compared. Results After surgery 6, 12, 24, 72 h, cTnI, CK-MB activity, sICAM-1 of observation group wrer lower than control group, after cardiopulmonary resuscitation 12, 24, 48 h, the number of patients with positive inotropic drugs were less than control group, the incidence of postoperative myocardial ischemia and atrial fibrillation was lower than the control group, the rates of auto resuscitation and left ventricular ejection fraction were higher than those of the control group, the differences were statistically significant (P < 0.05). Conclusion Propofol combined with Benazepril pretreatment can effectively reduce the myocardial ischemia-reperfusion injury in patients undergoing coronary artery bypass grafting under cardiopulmonary bypass, and has clinical value.
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