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| Current concepts and progress in the clinical diagnosis of intracranial germ cell tumors |
| WANG Haibin ZANG Li MU Yiming |
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Abstract Intracranial germ cell tumor is a kind of extragonadal germ cell tumors, mainly occurs in children and teenagers under the age of 20. Due to the diversity of its clinical manifestation, the types of histopathology and the pathogenic site, different treatment regimens are often needed. Therefore, earlier and accurate diagnosis can make targeted treatment earlier, reducing the damage to the central nervous system. The current clinical diagnosis relies mainly on the clinical manifestations, imaging, tumor markers, cerebrospinal fluid cytology and surgical biopsy pathology diagnosis. In addition, microRNA may be potentially valuable biomarkers in the diagnosis of intracranial germ cell tumors. This article mainly summarizes the current status and the progress of clinical diagnosis of intracranial germ cell tumors.
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[1] Echevarria ME，Fangusaro J，Goldman S. Pediatric central nervous system germ cell tumors：a review [J]. Oncologist，2008，13（6）：690-699.
[2] Murray MJ，Horan G，Lowis S，et al. Highlights from the third international central nervous system germ cell tumour symposium：laying the foundations for future consensus [J]. Ecancermedicalscience，2013，7（1）：1-10.
[3] McCarthy BJ，Shibui S，Kayama T，et al. Primary CNS germ cell tumors in Japan and the United States：an analysis of 4 tumor registries [J]. Neuro Oncol，2012，14（9）：1194-1200.
[4] Queipo G，Aguirre D，Nieto K，et al. Intracranial germ cell tumors：association with Klinefelter syndrome and sex chromosome aneuploidies [J]. Cytogenet Genome Res，2008，121（3-4）：211-214.
[5] Nodomi S，Umeda K，Ueno H，et al. Efficacy of ifosfamide-cisplatin-etoposide （ICE）Chemotherapy for a CNS Germinoma in a child with down syndrome [J]. J Pediatr Hematol Oncol，2017，39（1）：e39-e42.
[6] Al-Mahfoudh R，Zakaria R，Irvine E，et al. The management of bifocal intracranial germinoma in children [J]. Child Nerv Syst，2014，30（4）：625-630.
[7] Osorio DS， Allen JC. Management of CNS germinoma [J]. CNS Oncol，2015，4（4）：273-279.
[8] Louis DN，Perry A，Reifenberger G，et al. The 2016 World Health Organization classification of tumors of the central nervous system：a summary [J]. Acta Neuropathol，2016， 131（6）：803-820.
[9] Jennings MT，Gelman R，Hochberg F. Intracranial germ-cell tumors：natural history and pathogenesis [J]. J Neurosurg，1985，63（2）：155-167.
[10] Kim JY，Park J. Understanding the treatment strategies of intracranial germ cell tumors： focusing on radiotherapy [J]. J Korean Neurosurg Soc，2015，57（5）：315-322.
[11] Matsutani M，Sano K，Takakura K，et al. Primary intracranial germ cell tumors：a clinical analysis of 153 histologically verified cases [J]. J Neurosurg，1997，86（3）：446-455.
[12] Sethi RV，Marino R，Niemierko A，et al. Delayed diagnosis in children with intracranial germ cell tumors [J]. J Pediatr，2013，163（5）：1448-1453.
[13] Crawford JR，Santi MR，Vezina G，et al. CNS germ cell tumor（CNSGCT）of childhood：presentation and delayed diagnosis [J]. Neurology，2007，68（20）：1668-1673.
[14] Nishiuchi T，Imachi H，Murao K，et al. Suprasellar germinoma masquerading as lymphocytic hypophysitis associated with central diabetes insipidus，delayed sexual development，and subsequent hypopituitarism [J]. Am J Med Sci，2010，339（2）：195-199.
[15] 边芳，汪宁，赵真真，等.颅内生殖细胞瘤致垂体柄增粗误诊为淋巴细胞性垂体炎临床报告并文献复习[J].临床误诊误治，2015，28（5）：53-56.
[16] Rivarola MA，Mendilaharzu H，Warman M，et al. Endocrine disorders in 66 suprasellar and pineal tumors of patients with prepubertal and pubertal ages [J]. Horm Res，1992， 37（1-2）：1-6.
[17] Lensing FD，Abele TA，Sivakumar W，et al. Pineal region masses-imaging findings and surgical approaches [J]. Curr Probl Diagn Radiol，2015，44（1）：76-87.
[18] Calaminus G，Bamberg M，Baranzelli MC，et al. Intracranial germ cell tumors：a comprehensive update of the European data [J]. Neuropediatrics，1994，25（1）：26-32.
[19] Kushner BH，LaQuaglia MP，Wollner N，et al. Desmoplastic small round-cell tumor：prolonged progression-free survival with aggressive multimodality therapy [J]. J Clin Oncol，1996，14（5）：1526-1531.
[20] Murray MJ，Bartels U，Nishikawa R，et al. Consensus on the management of intracranial germ-cell tumours [J]. Lancet Oncol，2015，16（9）：470-477.
[21] Murray MJ，Nicholson JC，Coleman N. Biology of childhood germ cell tumours，focussing on the significance of microRNAs [J]. Andrology，2015，3（1）：129-139.
[22] Esquela-Kerscher A，Slack FJ. Oncomirs-microRNAs with a role in cancer [J]. Nat Rev Cancer，2006，6（4）：259-269.
[23] Balzano F，Deiana M，Giudici SD，et al. MiRNA stability in frozen plasma samples [J]. Molecules，2015，20（10）：19030-19040.
[24] Mall C，Rocke DM，Durbin-Johnson B，et al. Stability of miRNA in human urine supports its biomarker potential [J]. Biomark Med，2013，7（4）：623-631.
[25] Canturk KM，Ozdemir M，Can C，et al. Investigation of key miRNAs and target genes in bladder cancer using miRNA profiling and bioinformatic tools [J]. Mol Biol Rep，2014，241（12）：8127-8135.
[26] Nassar FJ，Nasr R，Talhouk R. MicroRNAs as biomarkers for early breast cancer diagnosis，prognosis and therapy prediction [J]. Pharmacol Ther，2017，172：34-49.
[27] Mishra PJ. MicroRNAs as promising biomarkers in cancer diagnostics [J]. Biomark Res，2014，2（1）：19.
[28] Palmer RD，Murray MJ，Saini HK，et al. Malignant germ cell tumors display common microrna profiles resulting in global changes in expression of mRNA targets [J]. Cancer Res，2010，70（7）：2911-2923.
[29] Murray MJ，Halsall DJ，Hook CE，et al. Identification of microRNAs from the miR-371-373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors [J]. Am J Clin Pathol，2011，135（1）：119-125.
[30] Murray MJ，Bell E，Raby KL，et al. A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours [J]. Br J Cancer，2016，114（2）：151-162.
[31] Dieckmann KP，Radtke A，Spiekermann M，et al. Serum levels of microRNA miR-371a-3p：a sensitive and specific new biomarker for germ cell tumours [J]. Eur Urol，2017，71（2）：213-220. |
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