葡萄糖转运蛋白1在阿尔茨海默病中的作用研究进展

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Abstract Alzheimers disease (AD) is the most common type of dementia in the elderly. The incidence of Alzheimers disease is increasing year by year. At present, the pathogenesis of Alzheimers disease has not been fully elucidated and there is no effective preventive and therapeutic measures. Glucose transporter 1 (GLUT1) is a glucose transporter expressed mainly in the blood-brain barrier endothelial cells, which transports blood glucose to the brain tissue along the blood-brain barrier and provides energy for metabolism of brain cells. It is concluded that the expression of GLUT1 in the blood-brain barrier endothelial cells of AD patients is decreased, which may be related to the pathogenesis and pathological damage of AD. GLUT1 play a important role in the damage of blood-brain barrier integrity, amyloid β-peptide (Aβ) clearance and phosphorylation of tau. By reviewing relevant literatures in recent years, we hope to explore the GLUT1 in AD to provide a reference.

Key words： Alzheimers disease Glucose transporter 1 β-amyloid protein Phosphorylation of Tau

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	LI Weiping1 ZHANG Lei2 SHEN Yanfang2 DU Jumei2

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LI Weiping1 ZHANG Lei2 SHEN Yanfang2 DU Jumei2. Research process of glucose transpoter 1 in Alzheimers disease[J]. 中国医药导报, 2017, 14(14): 36-39.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I14/36

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