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Effects of a combination therapy with a compound Chinese medicine and an enteral nutrition powder in the treatment of mice with chronic obstructive pulmonary diseases |
DENG Yicai1△ LIU Wenzhen2△ CHEN Zihan2,3 ZHANG Yaxin2 YAN Shufeng2 ZHENG Zhiling2,3 DONG Fang1 CHEN Zhuo2 |
1.Department of Respiration Medicine, the Second Hospital in Fuzhou Affiliated to Xiamen University, Fujian Province, Fuzhou 350007, China;
2.Division of Chemical Biology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian Province, Fuzhou 350002;
3.Fuzhou No.1 High School, Fujian Province, Fuzhou 350100, China |
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Abstract Objective To evaluate the validity and safety of a combination therapy with a compound Chinese medicine and an enteral nutrition powder ensure on chronic obstructive pulmonary diseases (COPD). Methods Among 96 male mice, 24 mice were randomly selected as a normal control group, the other 72 mice were induced as COPD mice after 60-day smoking. These COPD mice were then randomly divided into 3 groups: COPD positive group, Ensure treatment group (0.558 g/mL Ensure, 0.1 mL/10 g mice), combination therapy group (0.558 g/mL Ensure, 0.1 mL/10 g mice+2.5 g/mL traditional Chinese medicin, 0.06 mL/10 g mice). The weights of all mice were monitored during the whole experimental period. The serologic tests were carried out before and at different time points (2 weeks or 5 weeks) after the treatments began. Meanwhile, histological examinations of their lungs were performed. Results Compared with the normal control group mice, COPD mice showed a lower amount of serum albumin (P < 0.05) and a higher level of serum aminotransferase activity (P < 0.05) with a much slower rate in weight gaining.
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Cite this article: |
DENG Yicai1△ LIU Wenzhen2△ CHEN Zihan2,3 ZHANG Yaxin2 YAN Shufeng2 ZHENG Zhiling2,3 DONG Fang1 CHEN Zhuo2. Effects of a combination therapy with a compound Chinese medicine and an enteral nutrition powder in the treatment of mice with chronic obstructive pulmonary diseases[J]. 中国医药导报, 2017, 14(14): 20-24.
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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I14/20 |
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