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| Effect of Tirofiban in the percutaneous coronary intervention of elderly patients with hish-risk non-ST-elevation acute coronary syndrome |
| CHEN Shijun YU Haoyue LU Hui HU Jiayong▲ |
| Department of Cardiology, Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, Chongqing 400042, China |
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Abstract [Abstract] Objective To observe the effect of Tirofiban in the percutaneous coronary intervention (PCI) for elderly patients with hish-risk non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods Three hundred and twenty cases of elderly patients with hish-risk NSTE-ACS receiving PCI in Daping Hospital and the Research Institute of Surgery of the Third Military Medical University from February 2012 to February 2015 were selected and divided into two groups including 162 cases of control group (conventional treatment) and 158 cases of observation group (conventional treatment + Tirofiban). The TIMI myocardial perfusion grading before and after PCI of the two groups was compared, the clinical efficacy of the two groups was analyzed, the platelet aggregation levels and platelet count of the two groups were measured, the incidence of major adverse cardiovascular event (MACE) was recorded after a follow-up period of 30 d, and the incidence of bleeding complications was observed. Results The TIMI myocardial perfusion grades after PCI were significantly better than the control group (P ＜ 0.05); the total effective rate of observation group was 93.7%, which was significantly higher than that of control group (87.0%) (P ＜ 0.05); the platelet aggregation rate after PCI in observation group (0.29±0.09) was also significantly lower than that of control group (0.40±0.10) (P ＜ 0.05); follow-up for 30 d after PCI, the incidence of MACE in observation group (8.9%) was significantly lower than that of control group (14.2%) (P ＜ 0.05); while the incidence of bleeding complications between the two groups had no significant differences (P ＞ 0.05). Conclusion For elderly patients with hish-risk NSTE-ACS, Tirofiban can significantly improve TIMI myocardial perfusion levels, reduce platelet aggregation, improve clinical efficacy and short-term clinical prognosis, without increasing the risk of bleeding, which is worthy of clinical application.
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