西妥昔单抗联合化疗治疗中晚期食管癌的临床观察

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Abstract Objective To investigate the clinical observation of Cetuximab combined with Chemotherapy in the treatment of middle and advanced esophageal cancer. Methods Eighty patients with advanced esophageal cancer admitted to Tongde Hospital Affiliated to Zhejiang Chinese Medical University from February 2013 to May 2016 were selected as research objects. Patients were divided into control group (n = 40) and study group (n = 40) by random number table method. The control group was given Fluorouracil combined with cisplatin (FP) chemotherapy, and the study group was combined with Cetuximab on the basis of the conttol group. The clinical efficacy, tumor marker level, quality of life, survival rate and adverse reactions of the two groups were compared. Results The total clinical response rate of the study group was higher than that of the control group (P ＜ 0.05). After 4 cycles of treatment, SCC and CEA were decreased in both groups, and the study group were lower than those in the control group (P ＜ 0.05). EORTC QLQ-C30 scale score was increased in both groups after 4 cycles of treatment, and the group was higher than the control group (P ＜ 0.05). The survival rate of the study group was higher than that of the control group after follow-up of 12, 18 and 24 months, but there were no statistically significant difference between the two groups (P ＞ 0.05). There was no statistically significant difference between the two groups in the incidence of adverse reactions during treatment (P ＞ 0.05). Conclusion Cetuximab combined with Chemotherapy in the treatment of advanced esophageal cancer has a definite effect, can effectively improve the level of tumor markers, improve the quality of life of patients, without increasing the incidence of adverse reactions, and has a high clinical application value.

Key words： Cetuximab Chemotherapy Middle and advanced stage Esophageal cancer Clinical efficacy

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	LIU Zhijun HE Zhongliang CHEN Guoxing HE Xueming

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LIU Zhijun HE Zhongliang CHEN Guoxing HE Xueming. Clinical observation of Cetuximab combined with Chemotherapy in the treatment of middle and advanced esophageal cancer[J]. 中国医药导报, 2019, 16(23): 156-159.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I23/156

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