ⅢB/Ⅳ期肺癌患者放疗前后中医辨证分型与RAD51的关系

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Abstract Objective To investigate the relationship between traditional Chinese medicine syndrome differentiation and serum levels of RAD51 in patients with stage ⅢB/Ⅳ non-small cell lung cancer (NSCLC) before and after radiotherapy. Methods From May 2015 to May 2018, 85 patients with stage ⅢB/Ⅳ NSCLC admitted to the Department of Oncology of No.476 Hospital of the Joint Logistics Team of PLA were selected. The syndrome differentiation of traditional Chinese medicine was carried out in these NSCLC patients before and after radiotherapy, and serum levels of RAD51 were measured by the enzyme-linked immunosorbent assay method. The changes of traditional Chinese medicine syndromes, clinical efficacy, occurrence of radioactive pneumonia, expression changes of RAD51 and the relationship between radiotherapy efficacy and RAD51 in NSLCL patients were compared. Results After radiotherapy, the percentage of NSLCL patients with syndrome of lung stagnation and phlegm and blood stasis, yin deficiency phlegm heat, spleen deficiency with damp phlegm had statistically significant differences compared with those before radiotherapy (P ＜ 0.05 or P < 0.01). The differences of clinical efficacy in different syndrome types were statistically significant (P ＜ 0.05). There was no statistically significant difference in the classification of radiation pneumonitis (P ＞ 0.05). After radiotherapy, the expression of RAD51 in patients with the syndrome of lung stagnation phlegm and blood stasis, yin deficiency phlegm heat, spleen deficiency with damp phlegm were significantly lower than those before radiotherapy, the differences were highly statistically significant (P ＜ 0.01). There was no significant difference in the expression of RAD51 in the patients with syndrome of deficiency of both qi and yin before and after radiotherapy (P ＞ 0.05). Conclusion Traditional Chinese medicine syndrome differentiation and RAD51 expression before and after radiotherapy are important for predicting the efficacy of NSCLC radiotherapy. The expression of RAD51 after radiotherapy can be used as the basis of traditional Chinese medicine syndrome differentiation. RAD51 and traditional Chinese medicine syndromes can complement each other to guide individualized radiotherapy. The expression of RAD51 after radiotherapy can be used as the evidence of traditional Chinese medicine syndrome differentiation. RAD51 and traditional Chinese medicine syndromes complement each other and serve as an effective way to guide individualized radiotherapy.

Key words： Non-small cell lung cancer Radiotherapy Syndrome differentiation RAD51

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	HUANG Qian1 XIE Fangwei2

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HUANG Qian1 XIE Fangwei2. Relationship between traditional Chinese medicine syndrome differentiation and RAD51 in stage ⅢB/Ⅳ non-small cell lung cancer patients before and after radiotherapy[J]. 中国医药导报, 2019, 16(23): 102-105.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I23/102

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