急性缺血性脑卒中患者血清淀粉样蛋白A、脂蛋白磷脂酶A2、同型半胱氨酸水平变化及临床意义

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Abstract Objective To investigate the level changes, clinical significance and diagnostic efficacy of serum amyloid A (SAA), lipoprotein phospholipase A2 (Lp-PLA2) and homocysteine (Hcy) in patients with acute ischemic stroke. Methods One hundred and twenty-two patients with acute ischemic stroke admitted to Suzhou Hospital of Integrated Chinese and Western Medicine (“our hospital” for short) from May 2017 to May 2018 were selected as the experimental group, and their serum levels of SAA, Lp-PLA2 and Hcy were measured. The patients were divided into mild group (n = 44), moderate group (n = 25) and severe group (n = 53) according to the National Institutes of Health stroke scale (NIHSS), and the patients were divided into large area group (n = 59), medium area group (n = 25) and small area group (n = 38) according to the area of the infarct. Another 50 healthy people in the same period in our hospital were selected as the control group. The serum levels of SAA, Lp-PLA2 and Hcy were compared between the experimental group and the control group, and between different subgroups of the experimental group. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic values of serum SAA, Lp-PLA2, Hcy in patients with acute ischemic stroke. Results The serum levels of SAA, Lp-PLA2 and Hcy in the experimental group were significantly higher than those in the control group (P ＜ 0.01). In the experimental group, there were highly significant differences in serum levels of SAA, Lp-PLA2 and Hcy in groups with different degrees of severity and groups with different infarct areas (P ＜ 0.01), the serum levels of SAA, Lp-PLA2 and Hcy gradually increased with the aggravation of nerve function injury and the increase of infarction area. The diagnostic efficacy of combined detection of the three indicators for acute stroke was better than that of single detection. Conclusion The serum levels of SAA, Lp-PLA2 and Hcy in patients with acute ischemic stroke are significantly increased, which are increased with the increase of severity and infarct area. The combined detection of the three indicators is of great significance for the early diagnosis, screening and determination of the severity of cerebral infarction in patients with acute ischemic stroke.

Key words： Acute ischemic stroke Serum amyloid A Lipoprotein phospholipase A2 Homocysteine Diagnostic efficacy

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	ZHANG Tan LUO Yi ZHANG Qiang

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ZHANG Tan LUO Yi ZHANG Qiang. Level changes and clinical significance of serum amyloid A, lipoprotein phospholipase A2 and homocysteine in patients with acute ischemic stroke[J]. 中国医药导报, 2019, 16(23): 77-81.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I23/77

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