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| Research progress of miRNA in the Toll-like receptor signaling pathway of rheumatoid arthritis |
| ZHANG Na ZHANG Liyun ZHANG Gailian GAO Jinfang MA Dan LI Juan XU Ke |
| Department of Rheumatology, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Shanxi Province, Taiyuan 030000, China |
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Abstract Rheumatoid arthritis (RA) is an autoimmune disease with progressive destruction of cartilage and bone caused by chronic synovial hyperplasia. It has a high rate of disability and teratogenesis, and the etiology is not fully understood. At present, the treatment of RA mainly includes non-steroidal anti-inflammatory drugs, hormones, slow-acting anti-rheumatic drugs and biological agents. Although it improves the remission rate of the disease, it can not repair the damaged joints that have been formed, and there are many disadvantages, such as large side effects and high price. Therefore, it is urgent to find a new treatment method, and to understand the pathogenesis of RA in depth. Mechanisms are particularly critical. This review summarizes the regulatory role of miRNA in RA Toll-like receptor signaling pathway in order to provide reference for finding new therapeutic targets for RA.
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