靶向自噬治疗２型糖尿病合并非酒精性脂肪性肝病的机制研究

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Abstract Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for advanced liver disease, type 2 diabetes mellitus (T2DM), and cardiovascular diseases. T2DM is always accompanied by NAFLD as result of a common pathogenesis. Hepatic lipid accumulation and mitochondrial dysfunction proved to be two essential mechanisms for the pathogenesis of T2DM with NAFLD. Regulation of lipophagy and mitophagy in hepatocyte are potential targets for disease therapy. However, autophagy is considered to be a double-edged sword. Moderate autophagy protects liver, yet excessive or failure one aggravates its injury. The evolution of NAFLD could be associated with dynamic regulation of autophagy and additional studies are required. This review aims to investigate the potential value of autophagy regulation in the treatment of NAFLD in type 2 diabetes mellitus, in order to provide innovative targets for therapeutic intervention.

Key words： Non-alcoholic fatty liver disease Type 2 diabetes mellitus Lipophagy Mitophagy

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	YU Xinyang SHAO Ning KUANG Hongyu▲

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YU Xinyang SHAO Ning KUANG Hongyu▲. Mechanism research on targeted autophagy therapy of non-alcoholic fatty liver disease in type 2 diabetes mellitus[J]. 中国医药导报, 2017, 14(15): 43-46.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I15/43

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