血清降钙素原和高敏C反应蛋白在慢性阻塞性肺疾病急性加重期早期诊断中的应用

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (589 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the diagnostic value of serum procalcitonin (PCT) and hypersensitive C-reactive protein (hs-CRP) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods From January 2016 to September 2018, according to whether the patient had fever, cough, yellow phlegm and acute attack and the increase of white blood cells and neutrophils (common manifestations of bacterial infections), AECOPD patients from Hepingli Hospital of Dongcheng District in Beijing City were divided into infection group (52 cases) and non-infection group (48 cases). Another 100 chronic obstructive pulmonary disease (COPD) patients were collected as control group. The changes of serum PCT and hs-CRP levels before and after AECOPD treatment were compared. Results The levels of serum PCT and hs-CRP in AECOPD group were significantly higher than those in COPD group, and the difference was statistically significant (P ＜ 0.05). Before treatment, the levels of serum PCT and hs-CRP in infection group were significantly higher than those in non-infection group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of serum PCT and hs-CRP in infection group and non-infection group were significantly lower than those before treatment, and the level of indicators in infection group was significantly higher than that in non-infection group, the difference was statistically significant (P ＜ 0.05). Conclusion Serum PCT and hs-CRP are valuable for the early diagnosis of AECOPD and whether the patient suffer infection, and can be used to evaluate the efficacy of AECOPD.

Key words： Procalcitonin High sensitivity C reactive protein Acute exacerbation of chronic obstructive pulmonary disease Early diagnosis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIU Na

Cite this article:

LIU Na. Application of serum procalcitonin and high-sensitivity C-reactive protein in early diagnosis of acute exacerbation of chronic obstructive pulmonary disease[J]. 中国医药导报, 2019, 16(20): 148-151.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/148

[1] 史彩雯，施宇佳，陈意，等.急性加重期慢性阻塞性肺病患者血清C反应蛋白、降钙素原的临床价值[J].实用临床医药杂志，2018，22（17）：26-28.
[2] Gosens W，Van′t Hul AJ，Oomen JM，et al. Mechanical efficiency in chronic obstructive pulmonary disease [J]. J Cardiopulm Rehabil Prev，2017，37（2）：146-153.
[3] 柳骥戎，蒋丽，胡力，等.AECOPD患者NPPV不同压力支持水平对腹内压力的影响[J].现代生物医学进展，2016， 16（15）：2965-2968.
[4] Wedzicha JA，Singh R，Mackay AJ. Acute COPD exacerbations [J]. Clin Chest Med，2014，35（1）：157-163.
[5] Neukamm A，Einvik G，Didrik Hiseth A，et al. The prognostic value of measurement of high-sensitive cardiac troponin T for mortality in a cohort of stable chronic obstructive pulmonary disease patients [J]. BMC Pulm Med，2016，16（1）：164.
[6] Kuwano K，Araya J，Hara H，et al. Cellular senescence and autophagy in the pathogenesis of chronic obstructive pulmonary disease （COPD） and idiopathic pulmonary fibrosis （IPF） [J]. Respir Investig，2016，54（6）：397-406.
[7] Gao D，Chen X，Wu H，et al. The levels of serum pro-calcitonin and high-sensitivity C-reactive protein in the early diagnosis of chronic obstructive pulmonary disease during acute exacerbation [J]. Exp The Med，2017，14（1）：193-198.
[8] Chen W，Thomas J，Sadatsafavi M，et al. Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease：a systematic review and meta-analysis [J]. Lancet Respir Med，2015，3（8）：631-639.
[9] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南（2013年修订版）[J].中国医学前沿杂志：电子版，2014，6（2）：67-80.
[10] 降钙素原急诊临床应用专家共识组.降钙素原（PCT）急诊临床应用的专家共识[J].中华急诊医学杂志，2012， 21（9）：944-951.
[11] 陈文彬，潘祥林.诊断学[M].7版.北京：人民卫生出版社，2008：442-443.
[12] 徐蓓峥，罗勇，施静，等.慢性阻塞性肺疾病急性加重期患者血清PCT、CRP动态变化及回归分析[J].临床肺科杂志，2016，21（8）：1368-1371.
[13] 刘玉玲，赵小慧，张克武.降钙素原与超敏C-反应蛋白在慢性阻塞性肺疾病急性加重期中的临床意义[J].中国煤炭工业医学杂志，2012，15（9）：1384-1385.
[14] Snider RH，NylenES，BeckerKL. Procalcitonin and its component peptidesin systemic inflammation：immunochenmical characterization [J]. J Investid Med，1997，45：552.
[15] 石婷婷，李双庆，梁利波.降钙素原在感染中的应用及研究进展[J].中华全科医学，2018，16（4）：620-625.
[16] 张艳平，周鹂婕.C-反应蛋白联合降钙素原对慢性阻塞性肺病急性加重期中细菌感染的诊疗价值[J].中南大学学报：医学版，2014，39（9）：939-943.
[17] 王军，朱祥，黄娴，等.血清C反应蛋白和降钙素原在慢性阻塞性肺疾病急性加重期中的临床应用[J].当代医学，2015，21（35）：43-44.
[18] Celli BR， Cote CG， Marin JM，et al. The body-mass index，airflow obstruction，dyspnea，and exercise capacity index in chronic obstructive pulmonary disease [J]. N Engl J Med，2004，350（10）：1005-1012.
[19] 付云杰.CRP、PCT、WBC、Neu%及ESR对慢性阻塞性肺疾病急性加重期细菌感染的诊断价值[J].中国现代医生，2017，55（36）：23-25，29.
[20] 陈绍轩，莫夏鹰，黎满，等.联合检测CRP、PCT和ESR对诊断AECOPD细菌感染的临床价值[J].中国医药科学，2018，8（11）：130-132.
[21] 靳生艳，黄文辉，王蓉，等.肺癌患者姑息治疗后肺部感染病原菌分布与耐药性分析[J].中华医院感染学杂志，2016，26（15）：3392-3394.
[22] 要国华，彭玉娜，谭获.晚期肺癌合并肺部感染的临床研究[J].临床肺科杂志，2014，18（5）：798-800.
[23] 张章国，张燕，李小燕，等.慢性阻塞性肺病患者血液前降钙素原、超敏C反应蛋白水平变化及其临床意义[J].中国卫生检验杂志，2016，26（8）：1128-1130.
[24] 王利军.中老年慢性阻塞性肺疾病急性加重期并发感染患者血清PCT及CRP的临床价值研究[J].河北医学，2017，23（2）：278-280.
[25] 王春娟.血清降钙素原及高敏C反应蛋白水平检测在慢性阻塞性肺疾病急性加重期临床诊断中的意义[J].中国药物与临床，2018，18（S1）：95-97.