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| Value of detection of VEGF，EGFR and CD40 in differential diagnosis of benign and malignant pleural effusion |
| DING Yan1 ZHOU Jianrong1 SHUAI Ping2 LIAO Changfeng3 WANG Ying1 YUAN Xiaoliang1 |
1.Department of Respiration, the First Affiliated Hospital of Gannan Medical University, Jiangxi Province, Ganzhou 341000, China;
2.Department of Pathology, the First Affiliated Hospital of Gannan Medical University, Jiangxi Province, Ganzhou 341000, China;
3.Blood Laboratory, the First Affiliated Hospital of Gannan Medical University, Jiangxi Province, Ganzhou 341000, China |
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Abstract Objective To explore the value of detecting vascular endothelial growth factor (VEGF), epidermal growth factor (EGFR) and CD40 in differential diagnosis of benign and malignant pleural effusion. Methods Sixty patients with lung cancer and pleural effusion hospitalized and diagnosed in the First Affiliated Hospital of Gannan Medical University from June 2015 to June 2017 were selected as observation group. 60 tuberculous pleurisy patients with pleural effusion in the same period were selected as control group. The expression levels of VEGF, EGFR and CD40 in pleural effusion samples of all patients were detected and compared between two groups. The diagnostic value of each index for malignant pleural effusion was analyzed by receiver operating characteristic curve (ROC). Results The expression level of VEGF, EGFR and CD40 in pleural effusion of observation group was significantly higher than those of control group, the difference was statistically significant (P ＜ 0.05). ROC curve analysis showed that the area under the curve of VEGF in the diagnosis of malignant pleural effusion was 0.840, with 893.50 pg/mL as the cut-off point, the sensitivity was 70.00%, and the specificity was 91.70%. The area under the curve of EGFR in the diagnosis of malignant pleural effusion was 0.839, and the cut-off point was 29.50 mg/L. The sensitivity was 80.00% and specificity was 88.30%. The area under the curve of CD40 in the diagnosis of malignant pleural effusion was 0.911, and the cut-off point was 41.50 pg/mL. The sensitivity was 85.00% and the specificity was 93.30%. The diagnostic efficiency of CD40 in benign and malignant pleural effusion was better than that of VEGF and EGFR. Conclusion The expression of VEGF, EGFR and CD40 in malignant pleural effusion is significantly increased, the three methods have certain diagnostic value in differentiating benign and malignant pleural effusion. However, the sensitivity and specificity of CD40 in the diagnosis of malignant pleural effusion is higher than that of VEGF and EGFR.
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