急性发作期成人支气管哮喘患者外周血IL-27表达及临床意义

Abstract
Figure/Table
References (23)
Related Citation (15)

Download: PDF (584 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study expression and clinical significance of IL-27 in adults with bronchial asthma ("asthma" for short) during acute attack stage. Methods Ninety-seven cases of adults with asthma were selected from the Third People′s Hospital of Dongguan City in Guangdong Province from January 2016 to January 2017. They were divided into seizure group (54 cases) and remission group (43 cases) according to symptoms and signs, another 40 cases healthy adults were selected as control group at the same time. The serum level of immunoglobulin E (IgE), interferon-γ (IFN-γ), interleukin (IL)-12, IL-27 and transforming growth factor-β (TGF-β) was measured and compared in all the researchers. Canon AS-505 pulmonary function instrument was used to measure the percentage of forced expiratory volume in the first second (FEV1% pred) and the maximum expiratory rate in the first second (FEV1/FVC). The correlation of the above indicators were analyzed. Results IgE and TGF-β in remission group and seizure group were significantly higher than those in control group (all P ＜ 0.05), and seizure group was higher than remission group (all P ＜ 0.05). The levels of IFN-γ, IL-12 and IL-27 in remission group and seizure group were significantly lower than those in control group (all P ＜ 0.05), and IL-12 and IL-27 in seizure group were lower than those in remission group (all P ＜ 0.05). FEV1% pred and FEV1/FVC in seizure group were lower than those in remission group and control group (all P ＜ 0.05), FEV1% pred and FEV1/FVC in remission group were also lower than those in control group (all P ＜ 0.05). IgE and TGF-β were negatively correlated with FEV1% pred and FEV1/FVC (P ＜ 0.05). IFN-γ, IL-12 and IL-27 were positively correlated with FEV1% pred and FEV1/FVC (P ＜ 0.05). Conclusion Serum IL-27 in adults with asthma during acute attack stage is elevated, and it is positively correlated with pulmonary function status. It is important to evaluate the severity of asthma.

Key words： Asthma Acute attack stage Interleukin-27 Helper T cell

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WU Lei CHEN Cuiyi CHEN Jin′ai HUANG Yu′e CHEN Meihua

Cite this article:

WU Lei CHEN Cuiyi CHEN Jin′ai HUANG Yu′e CHEN Meihua. Expression and clinical significance of IL-27 in adults with bronchial asthma during acute attack stage[J]. 中国医药导报, 2019, 16(20): 137-140.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/137

[1] 中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南（2016年版）[J].中华结核和呼吸杂志，2016，39（9）：675-697.
[2] 尚云晓，冯雍.2014版全球哮喘防治创议（GINA）解读——与儿童哮喘相关内容[J].中国实用儿科杂志，2014， 29（9）：669-672.
[3] 全国儿科哮喘协作组.第三次中国城市儿童哮喘流行病学调查[J].中华儿科杂志，2013，51（10）：729-736.
[4] 陈欣，林江涛.我国支气管哮喘防治现状[J].内科急危重症杂志，2008，14（5）：225-226.
[5] 李学良，许朝霞，王忆勤.支气管哮喘发病机制的研究进展[J].中华中医药学刊，2012，30（9）：1960-1963.
[6] 孙海霞，张洪钦，刘波泉.支气管哮喘患者血清相关miRNAs的检测及其意义[J].中国医药导报，2017，14（13）：58-60.
[7] 朱飞，赵铭山.支气管哮喘与Th1/Th2/Th17的相关性分析[J].国际免疫学杂志，2017，40（2）：225-228.
[8] Yoshimoto T，Okada K，Morishima N，et al. Induction of IgG2a class switching in B cells by IL-27 [J].J Immunol，2004，173（4）：2479-2485.
[9] Al Ghobain MO，Al-Hajjaj MS，Al Moamary MS. Asthma prevalence among 16-to 18-year-old adolescents in Saudi Arabia using the ISAAC questionnaire [J]. BMC Public Health，2012，12：239.
[10] Boulet LP，Fitzgerald JM，Reddel HK. The revised 2014 GINA strategy report：opportunities for change [J]. Curr Opin Pulm Med，2015，21（1）：1-7.
[11] 孙德彬，熊雪芳，周家峰，等.哮喘患者外周血调节性T细胞和Th1/Th2的变化及其与哮喘病情的关系[J].中国现代医生，2016，54（16）：6-9.
[12] 扶红根，雷后兴.白介素-35与支气管哮喘的相关性研究进展[J].中国免疫学杂志，2016（1）：123-126.
[13] Woodruff PG，Modrek B，Choy DF，et al. T-helper type 2-driven inflammation defines major subphenotypes of Asthma [J]. Am J Respir Crit Care Med，2009，180（5）：388-395.
[14] 程思，邵天波，郭晓静.哮喘患者外周血调节性T细胞和Th1/Th2的变化及与病情的相关性分析[J].河北医学，2017，23（4）：699-702.
[15] van der Pouw Kraan TC，Boeije LC，de Groot ER，et al. Reduced production of IL-12 and IL-12-dependent IFN-gamma release in patients with allergic asthma [J]. J Immunol，1997，158（11）：5560-5565.
[16] Wen FQ，Liu X，Manda W，et al. TH2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids [J]. J Allergy Clin Immunol，2003，111（6）：1307-1318.
[17] 黄花荣，吴敬芳.IFN-γ与IL-4基因多态性与儿童哮喘易感性及外周血IFN-γ、IL-4和IgE的关系[J].中国病理生理杂志，2010，26（9）：1769-1775.
[18] Pflanz S，Timans JC，Cheung J，et al. IL-27，a heterodimeric cytokine composed of EBI3 and p28 protein，induces proliferation of naive CD4+T cells [J]. Immunity，2002，16（6）：779-790.
[19] Owaki T，Asakawa M，Morishima N，et al. A role for IL-27 in early regulation of Th1 differentiation [J]. J Immunol，2005，175（4）：2191-2200.
[20] Wirtz S，Tubbe I，Galle PR，et al. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27 [J]. J Exp Med，2006，203（8）：1875-1881.
[21] Laible J，Barkey HJ. Positive and negative regulation of the IL-27 receptor during lymphoid cell activation [J]. J Immunol，2005，174（12）：7684.
[22] Sharma S，Raby BA，Hunninghake GM，et al. Variants in TGFB1，dust mite exposure，and disease severity in children with Asthma [J]. Am J Respir Crit Care Med，2009， 179（5）：356.
[23] Saito A，Okazaki H，Sugawara I，et al. Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro [J]. Int Arch Allergy Immunol，2003，132（2）：168-176.