大株红景天注射液对晚期乳腺癌患者生活质量和免疫功能的影响

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Abstract Objective To observe the effects of Sofren Injection on quality of life and immune function in patients with advanced breast cancer. Methods Form June 2014 to June 2016, 56 cases of breast cancer patients with Ⅳ stage who received chemotherapy treatment in Hengshui Harrison International Peace Hospital were selected and divided into observation group and control group by the random number table method, with 28 cases in each group. Both groups selected Paclitaxel combined with Cisplatin chemotherapy regiments, and the observation group was given Sofren Injection by intravenous drip on the basis of the chemotherapy regiments. After 2 cycles of chemotherapy, the clinical efficacy was monitored and evaluated. The indexes related to cell immunology in the two groups were observed: CD3+, CD4+, CD4+/CD8+, CD8+ and NK values were measured and calculated before and after chemical drug treatment in the two groups. The blood routine, liver and kidney function and cardiac function of the patients were measured, and the adverse drug reactions and grades during the hospitalization were recorded. Results After 2 cycles of treatment, CD3+, CD4+, CD4+/CD8+ and NK cells in the two groups were all higher than those before chemotherapy, and CD8+ was lower than before treatment, with statistically significant differences (P < 0.05). CD3+, CD4+, CD4+/CD8+ and NK cells in the observation group were significantly higher than those in the control group after treatment, CD8+ was lower than that of the control group, and the difference was statistically significant (P ＜ 0.05). The incidence of cardiotoxicity, nausea and vomiting in the observation group was significantly lower than that in the control group during the combined treatment, with statistically significant differences (P ＜ 0.05). The improvement rate of life quality in the observation group was better than that in the control group, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference in efficacy between the two groups (P ＞ 0.05). Conclusion Large strains of Sofren Injection combined with chemotherapy drugs can significantly improve the cellular immunity and quality of life of patients with advanced breast cancer.

Key words： Sofren Injection Advanced breast cancer Immunologic function Life quality

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	SU Guoxin ZHU Xiaoli SU Yaping LI Lingling CHEN Hejun CHONG Baogui MA Hongfang▲

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SU Guoxin ZHU Xiaoli SU Yaping LI Lingling CHEN Hejun CHONG Baogui MA Hongfang▲. Effects of Sofren Injection on quality of life and immune function in patients with advanced breast cancer[J]. 中国医药导报, 2019, 16(20): 133-136.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/133

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