胃癌患者外周血中性粒细胞及血小板与淋巴细胞比值与胃癌病理特征之间的关系

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Abstract Objective To explore the correlation of serum neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with pathological features of gastric cancer in patients with gastric cancer. Methods A total of 457 patients with gastric cancer who were admitted to the Affiliated Hospital of Xuzhou Medical University (“our hospital” for short) from January 2015 to August 2018 were enrolled in the study. The 200 healthy people taken physical examination in our hospital during the same period were used as the control group. The differences of NLR and PLR between the two groups were analyzed retrospectively. And the correlation between tumor invasion depth or lymph node metastasis or TNM staging and NLR or PLR was analyzed. Results NLR and PLR in the gastric cancer group were significantly higher than those in the control group, and the difference was statistically significant (P < 0.05). The patients in NLR elevation group (NLR≥2.44) were more likely to have larger tumor diameters, worse differentiation, deeper infiltration depth, more lymph node metastasis, and later TNM than those in the NLR reduction group （NLR<2.44）, as well as PLR elevation group (PLR≥176.59) compared with PLR reduction group (PLR<176.59) (P < 0.05). The proportion of lymph node metastasis in patients with NLR elevation + PLR elevation group was significantly higher than that in NLR reduction + PLR elevation, NLR elevation + PLR reduction and NLR reduction + PLR reduction groups (P < 0.05). The lymph node metastasis rate of NLR reduction + PLR elevation group and NLR elevation + PLR reduction group was significantly higher than NLR reduction + PLR reduction group (P < 0.05), there was no significant difference in lymph node metastasis rate among the other groups (P > 0.05). There was a significant positive correlation between NLR and PLR (r = 0.648, P < 0.05). Conclusion The higher the NLR and PLR of gastric cancer patients, the deeper the degree of tumor infiltration, the lower the degree of differentiation, the greater the number of lymph node metastases, the larger the tumor diameter and the later the TNM stage, the worse the prognosis.

Key words： Gastric cancer Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Lymphatic metastasis

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	LIU Junliang1 WANG Ziwen1 FEI Sujuan2

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LIU Junliang1 WANG Ziwen1 FEI Sujuan2. Relationship between the ratio of peripheral blood neutrophils and platelet to lymphocytes in patients with gastric cancer and the pathological characteristics of gastric cancer[J]. 中国医药导报, 2019, 16(20): 116-120.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/116

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