宫腔灌注地塞米松对中重度宫腔粘连子宫内膜E2R、TGF-■1、VEGF的影响

Abstract
Figure/Table
References (21)
Related Citation (15)

Download: PDF (575 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effect of intrauterine perfusion of Dexamethasone on the estradiol receptor (E2R), transfotruing growth factor-beta 1 (TGF-β1), vescular endothelial growth factor (VEGF) of endometrium with moderate and severe intrauterine adhesion. Methods From October 2016 to June 2017, 120 patients with moderate and severe intrauterine adhesion in Nanshan District People′s Hospital of Shenzhen City, Guangdong Province were selected as the research objects, and they were divided into research group and control group by the random number group, with 60 cases in each group. The research group were given Dexamethasone 5 mg + normal saline 10 mL of perfusion palace 10 min; and the control group was perfused with the same amount of normal saline. The level changes of E2R, TGF-β1 and VEGF before and after artificial treatment were observed. Results There were statistically significant differences in the total effective treatment for 1 and 3 months after artificial treatment between the two groups (P < 0.05); the total effective rate of research group 3 months after artificial treatment was higher than that 1 month after artificial treatment, the difference was statistically significant (P < 0.05). The E2R, TGF-β1 and VEGF of the two groups 1 and 3 months of after artificial treatment were all lower than those before treatment of the same group, and those 3 months after artificial treatment were lower than 1 month after artificial treatment, the differences were statistically significant (P < 0.05). The E2R, TGF-β1 and VEGF of the research group 1 and 3 months after artificial treatment were all lower than those of the control group, the differences were statistically significant (P < 0.05). Conclusion Dexamethasone can alter the expression of E2R, TGF-β1 and VEGF in endometrium samples, and can assist in the post-hysteroscopic treatment of patients with moderate and severe intrauterine adhesion by intrauterine perfusion.

Key words： Intrauterine perfusion Dexamethasone Moderate and severe intrauterine adhesion Endometrium Cytosolic estradiol receptor Transfotruing growth factor-β1 Vescular endothelium growth factor

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WEI Shu1 YAO Hong2 ZHANG Yucui1

Cite this article:

WEI Shu1 YAO Hong2 ZHANG Yucui1. Effect of Dexamethasone intrauterine perfusion on E2R, TGF- beta 1 and VEGF in endometrium with moderate and severe intrauterine adhesion[J]. 中国医药导报, 2019, 16(20): 108-111.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/108

[1] Kuramoto G，Takagi S，Ishitani K，et al. Preventive effect of oral mucosal epithelial cell sheets on intrauterine adhesions [J]. Hum Reprod，2015，30（2）：406-416.
[2] 池余刚，雷丽，刘禄斌，等.小剂量阿司匹林对于重度宫腔粘连电切术后子宫内膜的影响[J].重庆医学，2015，44（28）：3944-3946.
[3] 陈滢，王晶，黄惠娟，等.宫型节育器对中重度宫腔粘连患者子宫内膜CTGF、PDGF的影响[J].华南国防医学杂志，2015，29（12）：905-907.
[4] 陈建凤.雌孕激素治疗联合补肾祛瘀法对中重度宫腔粘连宫腔镜分离术后疗效改善的分析[J].中国计划生育学杂志，2017，25（1）：43-46.
[5] Xue X，Chen Q，Zhao G，et al. The Overexpression of TGF-β and CCN2 in Intrauterine Adhesions Involves the NF-κB Signaling Pathway [J]. PLoS One，2015，10（12）：e0146159.
[6] 李学广，郑利会，葛继帮.经阴道三维超声成像对宫腔粘连的临床诊断价值探析[J].中国医药指南，2015，13（29）：182-183.
[7] 陈灿明，王奕芳，顾小燕，等.宫腔粘连病因学及治疗研究进展[J].国际妇产科学杂志，2016，43（3）：250-253.
[8] 付婷，游存厚，吕悦.ER、PR、VEGF和TGF-β1在绝经后子宫内膜息肉中的表达[J].中国保健营养，2016，26（19）：56-57.
[9] 李桃英，高珊珊，刘鹏森，等.ER、VEGF、TGF-β1在增生期子宫内膜良恶性肿瘤中的表达及其相关性研究[J].实用癌症杂志，2018，23（3）：96-97.
[10] 周龙书，李李，史文静.Vasohibin-1、VEGF在子宫内膜腺癌中的表达及意义[J].中国妇幼保健，2015，30（3）：350-352.
[11] 梁朵献.雌激素受体、血管内皮生长因子、转化生长因子-β1在增生期子宫内膜息肉组织中的表达[J].肿瘤基础与临床，2017，5（5）：372-374.
[12] 杨欢，常亚杰，陈玉清.重度宫腔粘连子宫内膜修复中微血管密度及VEGF的表达及其临床意义[J].新医学，2016，47（10）：671-675.
[13] 邱华娟，梁朵献，孙颖，等.子宫内膜息肉中雌激素受体、血管内皮生长因子和转化生长因子-β1的表达及相关性研究[J].中国妇幼保健，2017，32（5）：928-930.
[14] 陈玉清，常亚杰，杨欢.重度宫腔粘连子宫内膜修复中微血管密度及VEGF的表达及其临床意义[J].新医学，2016，47（10）：671-675.
[15] 曾薇薇，姚吉龙，史文娟，等.氧化再生纤维素防粘连膜在重度宫腔粘连治疗中的作用及其对转化生长因子β1表达的影响[J].现代妇产科进展，2016，25（1）：22-24，28.
[16] 杜艳芳，孙燕.ER、PR和NF-κB在宫腔粘连子宫内膜组织中的表达及意义[J].广西医科大学学报，2016，33（4）：580-583.
[17] 徐洁，刘艳，郭遂群.雌激素受体及基质金属蛋白酶-9在宫腔粘连组织中的表达及意义[J].广东医学，2015， 36（8）：1222-1225.
[18] 郝帅，伍佳，罗超，等.帕洛诺司琼联合地塞米松对妇科腹腔镜手术术后恶心呕吐的预防效果[J].中国医药，2016，11（12）：1828-1832.
[19] 程化，薛超群，罗瑞雪.粘连性肠梗阻应用地塞米松治疗的临床效果分析[J].当代医学，2015，21（13）：113-114.
[20] 蒋月霞.术中应用右旋糖酐40联合地塞米松对腹腔粘连影响观察[J].中国实用医药，2014，8（24）：105-106.
[21] 赵小迎，金纬纬.纤维蛋白溶解系统和转化生长因子-1在子宫全切除术后腹腔粘连发病机制中的作用[J].中国现代医生，2017，55（9）：1-4.