血清miR-155联合HE4、CA199诊断子宫内膜癌的价值

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Abstract Objective To investigate the diagnostic values of serum miR-155 combined with human epididymal protein 4 (HE4) and carbohydrate antigen 199 (CA199) in endometrial cancer (EC). Methods Thirty-right patients with EC admitted to Oncology Department of Handan First Hospital in Hebei Province from June 2016 to June 2018 were selected as the EC group, 60 cases of endometrial hyperplasia patients were selected as the endometrial hyperplasia group, 60 healthy persons were taken as control group, the levels of serum microRNA-155, HE4 and CA199 were detected and compared among the three groups, and their diagnostic value for EC patients was analyzed. Results The levels of serum miR-155, HE4, and CA199 in EC group and endometrial hyperplasia group were higher than those in control group (P < 0.05), and those in EC group were higher than those in endometrial hyperplasia group (P < 0.05); the levels of serum miR-155, HE4, and CA199 in EC patients with pathological grades G3 and G2 were higher than those in patients with grade G1 (P < 0.05), while those in patients with grade G3 were higher than those in patients with grade G2 (P < 0.05); the levels of serum miR-155, HE4, and CA199 in EC patients with stage Ⅱ, Ⅲ, and Ⅳ of FIGO were higher than those in patients with stage Ⅲ (P < 0.05), those in patients with stage Ⅲ and Ⅳ were higher than those in patients with stage Ⅱ (P < 0.05), and those in patients with stage Ⅳ were higher than those in patients with stage Ⅲ (P < 0.05). The ROC curve showed that the AUC, sensitivity and specificity of the combined detection were higher than those of the single detection. Conclusion Serum miR-155, HE4, and CA199 are highly expressed in EC patients, and with the increases of pathological grade and FIGO stage, the sensitivity and specificity of the combined diagnosis are high, which has high clinical value for early diagnosis of EC patients.

Key words： Endometrial carcinoma MiR-155 Human epididymis protein 4 Carbohydrate antigen 199;

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	CHEN Yufen1 HAN Min1 ZHANG Xiujun1 SU Haifei2 ZHANG Xiao1

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CHEN Yufen1 HAN Min1 ZHANG Xiujun1 SU Haifei2 ZHANG Xiao1. Diagnostic values of serum MiR-155 combined with HE4 and CA199 in endometrial cancer[J]. 中国医药导报, 2019, 16(20): 100-103.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/100

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