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| Correlation between lymphovascular space invasion and prognosis of endometrial carcinoma |
| YANG Qian1，2 ZHOU Huaijun1，3▲ LING Jingxian3 LI Rong3 HAN Ke3 ZHU Xianghong3 TANG Xiaoqiu3 |
1.Drum Tower Clinical Medical College of Nanjing Medical University, Jiangsu Province, Nanjing 210008, China;
2.Department of Obstetrics and Gynecology, Nanjing Pukou Hospital, Jiangsu Province, Nanjing 210031, China;
3.Department of Gynecology, Nanjing Drum Tower Hospital, Jiangsu Province, Nanjing 210008, China |
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Abstract Objective To study the clinicopathological features and prognosis of endometrial carcinoma with lymphovascular space invasion (LVSI). Methods The data of 671 cases of endometrial carcinoma treated in Nanjing Drum Tower Hospital from January 2007 to December 2017 was retrospectively analyzed, including 120 cases in LVSI positive group and 551 cases in LVSI negative group. The clinicopathological information of patients was analyzed, and Kaplan-Meier curves were established. Univariate and multivariate analyses were performed. Results Compared with LVSI negative group, LVSI positive group was significantly higher in proporation of patients with menopause, late stage of operation and pathology, infiltration of deep muscle layer, poor tissue differentiation, lymph node metastasis, recurrence and death, the differences were statistically significant (P < 0.05). There was no statistical difference between the two groups in the proporation of patients with medical complications of hypertension, diabetes and uterine leiomyoma (P > 0.05). Multivariate analysis showed that cervical stroma involvement (OR = 0.342, 95%CI: 0.134-0.873, P < 0.05) and LVSI (OR = 0.110, 95%CI: 0.051-0.238, P < 0.01) were significantly correlated with lymph node metastasis. Survival rate analysis showed that both OS and RFS were significantly decreased in LVSI positive patients (P < 0.05). The results of COX regression showed that the survival time and outcome of endometrial carcinoma were affected by the late stage of operation and pathology, the nonendometrial carcinoma and LVSI (P < 0. 05). Conclusion LVSI is closely related to lymph node metastasis and may be an important predictor of lymph node metastasis. LVSI is an important risk factor for poor prognosis of endometrial carcinoma.
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