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| Analysis of risk factors for relapse of lacunar cerebral infarction in elderly men with alcohol addiction |
| LI Jie SONG Wei ZHANG Pengchuan PAN Weihua▲ |
| Department of Neurology, Beijing Daxing District Hospital of Integrated Traditional Chinese and Western Medicine, Beijing 100076, China |
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Abstract Objective To investigate the risk factors of lacunar cerebral infarction recurrence in elderly men with alcohol addiction. Methods Clinical data of 97 elderly male patients with alcohol addiction with lacunar cerebral infarction admitted to the Department of Neurology of Beijing Daxing District Hospital of Integrated Chinese and Western Medicine was retrospectively analyzed. According to their medical history, they were divided into the initial group (50 patients with the initial onset of a cavity obstruction) and the recurrence group (47 patients with ≥2 times recurrence of a cavity obstruction). The patient′s age, body mass index, amount of alcohol dependence, smoking history, and medical history were compared between the two groups, the method of multi-factor Logistic regression was used to analyze the related risk factors of lacunar cerebral infarction recurrence in elderly men with alcohol addiction, the Cochran-Armitage trend test was used to determine whether there was a linear trend between the daily alcohol dependence and the recurrence of lacunar cerebral infarction. Results The proportion of patients with hypertension, smoking history, diabetes history, hyperlipidemia history, atrial fibrillation history, transient ischemic attack history and daily alcohol dependence in the relapse group were significantly higher than those in the primary group (all P ＜ 0.05); the results of multivariate Logistic regression analysis showed that the history of diabetes, history of atrial fibrillation, history of transient cerebral ischemia and daily alcohol dependence were all risk factors for the recurrence of lacunar cerebral infarction in elderly males, with regression coefficients of 1.80, 1.06, 1.60 and 2.11, respectively. The corresponding P values were 0.03, 0.04, 0.04 and 0.01 respectively, analysis of Cochran-Armitage trend showed that there was a linear trend between the daily alcohol dependence of elderly men and the recurrence of lacunar cerebral infarction, and the correlation coefficient was r = 0.28, P = 0.01. Conclusion Clinical intervention should be strengthened for risk factors such as diabetes, atrial fibrillation, transient ischemic attack and daily alcohol dependence, so as to reduce the recurrence rate of lacunar cerebral infarction in elderly men.
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