舒肝解郁胶囊联合抗抑郁药治疗脑卒中后抑郁症的效果

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Abstract Objective To observe the effect of Shugan Jieyu Capsules combined with antidepressant in the treatment of post-stroke depression. Methods From July 2016 to July 2018, 128 patients with post-stroke depression (PSD) treated in the Inner Mongolia Mental Health Center were selected and divided into control group and observation group according to random number table method, with 64 patients in each group. The control group received conventional antidepressant treatment, and the observation group was treated with Shugan Jieyu Capsules on the basis of antidepressant. Both groups were treated for 6 weeks. Hamilton depression rating scale (HAMD) was used to evaluate the efficacy and depression degree. Neurological function was assessed using the National Institutes of health stroke scale (NIHSS). Quality of life was assessed by referring to the nurses′ observation scale for inpatient evaluation (NOSIE). Adverse reactions were observed in the two groups. Results The total effective rate of observation group was significantly higher than control group (P ＜ 0.01). After 6 weeks, the NIHSS score of the observation group was lower than that of the control group, and the difference was highly statistically significant (P ＜ 0.01). HAMD scores in the observation group after 6 weeks were lower than those in the control group (P ＜ 0.01). There was no statistically significant difference in the rate of adverse reactions between the two groups (P ＞ 0.05). Both groups showed mild nausea, headache, constipation and other reactions, which spontaneously subsided after 2-3 days. The scores of depression, personal hygiene, social interest and social ability of the observation group were lower than those of the control group (P ＜ 0.01). Conclusion The combined treatment of Shugan Jieyu Capsules and antidepressant for PSD has a definite effect, which can relieve the symptoms of depression, improve neurological function and the quality of life. Only mild headache, nausea and other reactions occur, with no serious adverse reactions, it is safe and effective.

Key words： Post-stroke depression Sertraline Escitalopram Neurological function Quality of life

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	TIAN Le ZHANG Huiru WANG Yi WANG Jianjun NI Jingjing JING Lan▲

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TIAN Le ZHANG Huiru WANG Yi WANG Jianjun NI Jingjing JING Lan▲. Effects of Shugan Jieyu Capsules combined with antidepressant in the treatment of post-stroke depression[J]. 中国医药导报, 2019, 16(20): 80-83.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/80

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