急性髓系白血病患者血清sPD-L1、VEGF表达及相关性

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Abstract Objective To investigate the expression and correlation of serum soluble programmed death ligand 1 (sPD-L1) and vascular endothelial growth factor (VEGF) of patients with acute myeloid leukemia. Methods Eighty-nine patients with acute myeloid leukemia admitted to Dongguan Kanghua Hospital (“our hospital” for short) from January 2015 to January 2018 were selected as research objects and enrolled into observation group, and 50 healthy subjects who underwent health examination in our hospital during the same period were selected as the control group. The sPD-L1 and VEGF levels of the two groups were detected by enzyme-linked immunosorbent assay (ELISA) and compared between the two groups. The patients in the observation group were treated with standardized therapy for 2 months, according to the criteria of curative effect, the patients were divided into complete remission (CR) group (36 cases), partial remission (PR) group (40 cases) and proceed (PD) group (13 cases), and the levels of sPD-L1 and VEGF in the three groups were detected and compared. The correlation between sPD-L1 and VEGF was also analyzed. Results Before treatment, the levels of sPD-L1 and VEGF in the observation group were significantly higher than those in the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the levels of sPD-L1 and VEGF in CR group and PR group were significantly lower than those in PD group, and the levels of sPD-L1 and VEGF in CR group were lower than those in PR group, the differences were statistically significant (P ＜ 0.05). Pearson correlation test showed that sPD-L1 was positively correlated with VEGF (r = 0.447, 0.327, all P ＜ 0.05). Conclusion The expression of sPD-L1 and VEGF in acute myeloid leukemia patients is high, and the levels of sPD-L1 and VEGF are decreased with the improvement of prognosis. Therefore, the detection of sPD-L1 and VEGF has certain assistant effects and clinical value for the diagnosis, treatment and prognosis evaluation of acute myeloid leukemia patients.

Key words： Acute myeloid leukemia Soluble programmed death ligand 1 Vascular endothelial growth factor Correlation

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	WU Fuqun1
	2 YIN Changxin3 DENG Shaotuan2 NIU Shiqiong2 YU Jianhua1 YAO Da′na1

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WU Fuqun1,2 YIN Changxin3 DENG Shaotuan2 NIU Shiqiong2 YU Jianhua1 YAO Da′na1. Expression and correlation of serum sPD-L1 and VEGF in patients with acute myeloid leukemia[J]. 中国医药导报, 2019, 16(20): 76-79,87.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/76

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