慢性心力衰竭患者血清S100B蛋白表达与RAGE水平的相关性研究及临床意义

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Abstract Objective To investigate the correlation between serum calcium binding protein B (S100B) expression and glycation end product receptor (RAGE) level in patients with chronic heart failure. Methods A total of 151 patients with chronic heart failure (observation group) and 150 healthy normal volunteers (control group) from the Second Affiliated Hospital of Hainan Medical University from January 2016 to February 2018 were selected. The levels of S100B, esRAGE and cRAGE were compared between the two groups and the correlation between S100B and esRAGE and cRAGE was analyzed. Results S100B and cRAGE in the observation group were significantly higher than those in the control group (P < 0.05), esRAGE was significantly lower than that in the control group (P < 0.05). S100B was negatively correlated with esRAGE (r = -0.876, P = 0.032), and S100B was positively correlated with cRAGE (r = 0.987, P = 0.028). Conclusion The severity of chronic heart failure is related to S100B and RAGE. The elevation of S100B in patients is correlated with the level of RAGE. The above indexes are abnormal, which has a good clinical value in the diagnosis and judgment of the disease.

Key words： Heart failure Serum calcium binding protein Glycosylation end product receptor Correlation

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	CHEN Yuewu LIU Xianxia CHEN Weiwei CHEN Lei CHEN Jiaxian ZHANG Yuansheng WU Xuezheng WU Xiaoyan

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CHEN Yuewu LIU Xianxia CHEN Weiwei CHEN Lei CHEN Jiaxian ZHANG Yuansheng WU Xuezheng WU Xiaoyan. Correlation between serum S100B protein expression and RAGE levels in patients with chronic heart failure and its clinical significance[J]. 中国医药导报, 2019, 16(20): 68-71.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/68

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