慢性心力衰竭患者红细胞分布宽度改变的影响因素分析

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Abstract Objective To investigate the influencing factors of red blood cell distribution width (RDW) in patients with chronic heart failure (CHF). Methods From September 2016 to May 2018, 136 patients with CHF who were hospitalized in the Department of Cardiovascular Medicine, Fenyang Hospital Affiliated to Shanxi Medical University were enrolled. According to the RDW level, patients were divided into low RDW group (RDW < 13.2%, 43 cases), medium RDW group (RDW = 13.2% - 14.5%, 47 cases) and high RDW group (RDW > 14.5%, 46 cases). The basic clinical data, laboratory data and activities of Na+/K+-ATPase and Ca2+/Mg2+-ATPase in erythrocyte membranes of the three groups were compared, and the factors affecting the changes of RDW in CHF patients were analyzed by multiple linear regression. Results There were significant differences in hemoglobin, albumin, direct bilirubin, left ventricular ejection fraction (LVEF), log N-terminal brain natriuretic peptide (NT-proBNP), Na+/K+-ATPase and Ca2+/Mg2+-ATPase activities in erythrocyte membrane among the groups (P < 0.05). RDW in patients with CHF was associated with LVEF, albumin, direct bilirubin, Na+/K+-ATPase, Ca2+/Mg2+-ATPase activity in erythrocyte membrane, and the regression coefficients were -0.104, -0.133, 0.111, -0.577, -0.263, respectively (P < 0.05). Conclusion LVEF, albumin, direct bilirubin, Na+/K+-ATPase and Ca2+/Mg2+-ATPase activity in erythrocyte membrane are the factors affecting RDW in patients with CHF. RDW has certain value in evaluating the condition, therapeutic effect and prognosis of CHF.

Key words： Chronic heart failure Red blood cell distribution width Direct bilirubin Albumin Na+/K+-ATPase activity in erythrocyte membrane Ca2+/Mg2+-ATPase activity in erythrocyte membrane

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	JIA Kaijian1 GUO Renwei1▲ WU Yunpeng2 GAO Shengli3 LI Li1

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JIA Kaijian1 GUO Renwei1▲ WU Yunpeng2 GAO Shengli3 LI Li1. Analysis of influencing factors of red blood cell distribution width in patients with chronic heart failure[J]. 中国医药导报, 2019, 16(20): 64-67.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/64

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