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| Research advances of adipose-derived stem cells on bone repair |
| ZHAO Daoyin1 NING Xu2 WANG Jian2 |
1.Guizhou Medical University, Guizhou Province, Guiyang 550004, China;
2.Department of Orthopedics, the Affiliated Hospital of Guizhou Medical University, Guizhou Province, Guiyang 550004, China |
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Abstract Bone tissue engineering consists of three main factors: stem cells for osteogenesis, growth factors for bone induction and biodegradable scaffolds for bone conduction. Mesenchymal stem cells have achieved significant success in repairing bone defects, and their safety has been demonstrated in a number of preclinical trials. Adipose-derived stem cell (ADSCs) can also differentiate into osteoblasts, chondrocytes, myocytes and adipocytes, and they have similar differentiation potential to BMSCs with a minimally invasive approach. Meanwhile, their yield is also higher than BMSCs, which has a broad clinical application prospect.
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