口腔鳞状细胞癌肿瘤微环境细胞间相互作用的研究进展

Abstract
Figure/Table
References (38)
Related Citation (7)

Download: PDF (649 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Oral squamous cell carcinoma (OSCC) tumor microenvironment (TME) includes tumor cells, tumor-associated macrophages (TAMs), tumor-associated fibroblasts (CAFs), and endothelial cells. During the occurrence and development of OSCC, tumor cells produce certain substances that affect the recruitment, differentiation and activation of TAMs and CAFs. TAMs and CAFs secrete cytokines to promote tumor cell proliferation, invasion, metastasis and other activities. The interaction between them forms a favorable TME, which plays an important role in the various stages of tumorigenesis and development. This article reviews the recent advances in the interaction of tumor cells with TAMs and CAFs and the role of CAFs in TAMs.

Key words： Oral squamous cell carcinoma Tumor-associated macrophages Cancer-associated fibroblasts Tumor microenvironment

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CAO Juan1 LIU Keke1 LIU Luyao1 ZHANG Wenwen1 LI Bo1 DONG Chunling2

Cite this article:

CAO Juan1 LIU Keke1 LIU Luyao1 ZHANG Wenwen1 LI Bo1 DONG Chunling2. Advances in research on cell-cell interactions in oral squamous cell carcinoma tumor microenvironment[J]. 中国医药导报, 2019, 16(20): 45-48.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/45

[1] Dourado MR，Guerra ENS，Salo T，et al. Prognostic value of the immunohistochemical detection of cancer-associated fibroblasts in oral cancer：A systematic review and meta-analysis [J]. J Oral Pathol Med，2018，47（5）：443-453.
[2] Utispan K，Koontongkaew S. Fibroblasts and macrophages：Key players in the head and neck cancer microenvironment [J]. JOB，2017，59（1）：23-30.
[3] Wang B，Liu H，Dong X，et al. High CD204（+） tumor-infiltrating macrophage density predicts a poor prognosis in patients with urothelial cell carcinoma of the bladder [J]. Oncotarget，2015，6（24）：20 204-20 214.
[4] Xiao M，Zhang J，Chen W，et al. M1-like tumor-associated macrophages activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma [J]. J Exp Clin Cancer Res，2018，37（1）：143.
[5] Marzano Rodrigues Petruzzi MN，Cherubini K，Salum FG，et al. Role of tumour-associated macrophages in oral squamous cells carcinoma progression：an update on current knowledge [J]. Diagn Pathol，2017，12（1）：32.
[6] Gao L，Wang FQ，Li HM，et al. CCL2/EGF positive feedback loop between cancer cells and macrophages promotes cell migration and invasion in head and neck squamous cell carcinoma [J]. Oncotarget，2016，7（52）：87 037-87 051.
[7] Pang X，Tang YL，Liang XH. Transforming growth factor- signaling in head and neck squamous cell carcinoma：Insights into cellular responses [J]. Oncol Lett，2018，16（4）：4799-4806.
[8] Sun H，Miao C，Liu W，et al. TGF-beta 1/T beta RII/Smad3 signaling pathway promotes VEGF expression in oral squamous cell carcinoma tumor-associated macrophages [J]. Biochem Biophys Res Commun，2018，497（2）：583-590.
[9] Kedmi M，Ben-Chetrit N，Koerner C，et al. EGF induces microRNAs that target suppressors of cell migration：miR-15b targets MTSS1 in breast cancer [J].Sci Signal，2015，8（368）：ra29.
[10] Liu ZC，Chen XH，Song HX，et al. Snail regulated by PKC/GSK-3 beta pathway is crucial for EGF-induced epithelial-mesenchymal transition （EMT） of cancer cells [J]. Cell Tissue Res，2014，358（2）：491-502.
[11] Nieto MA，Huang RY，Jackson RA，et al. EMT：2016 [J]. Cell，2016，166（1）：21-45.
[12] Lamouille S，Xu J，Derynck R. Molecular mechanisms of epithelial-mesenchymal transition [J]. Nat Rev Mol Cell Biol，2014，15（3）：178-196.
[13] Hu Y，He MY，Zhu LF，et al. Tumor- associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma [J]. J Exp Clin Cancer Res，2016，35：12.
[14] Piril?覿 E，V?覿yrynen O，Sundquist E，et al. Macrophages Modulate Migration and Invasion of Human Tongue Squamous Cell Carcinoma [J]. PLoS One，2015，10（3）：e0120895.
[15] Quan J，Elhousiny M，Johnson NW，et al. Transforming growth factor-beta 1 treatment of oral cancer induces epithelial-mesenchymal transition and promotes bone invasion via enhanced activity of osteoclasts [J]. Clin Exp Metastasis，2013，30（5）：659-670.
[16] Xu Q，Zhang Q，Ishida Y，et al. EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect [J]. Oncotarget，2017，8（6）：9557-9571.
[17] Kang Y，Zhang Y，Sun Y. Macrophage migration inhibitory factor is a novel prognostic marker for human oral squamous cell carcinoma [J]. Pathol Res Pract，2018，214（8）：1192-1198.
[18] Li YY，Tao YW，Gao S，et al. Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p [J]. E Bio Medicine，2018，36：209-220.
[19] Routray S，Sunkavali A，Bari KA. Carcinoma-associated fibroblasts，its implication in head and neck squamous cell carcinoma：a mini review [J]. Oral Dis，2014，20（3）：246-253.
[20] Sun Y. Translational Horizons in the Tumor Microenvironment：Harnessing Breakthroughs and Targeting Cures [J]. Med Res Rev，2015，35（2）：408-436.
[21] Puissant A，Fenouille N，Auberger P. When autophagy meets cancer through p62/SQSTM1 [J]. Am J Cancer Res，2012，2（4）：397-413.
[22] Kellermann MG，Sobral LM，da Silva SD，et al. Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts：Induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation [J]. Oral Oncol，2008，44（5）：509-517.
[23] Ding L，Ren J，Zhang D，et al. A novel stromal lncRNA signature reprograms fibroblasts to promote the growth of oral squamous cell carcinoma via LncRNA-CAF/interleukin-33 [J]. Carcinogenesis，2018，39（3）：397-406.
[24] Wu J，Hong Y，Wu T，et al. Stromal-epithelial lactate shuttle induced by tumor-derived interleukin-1 beta promotes cell proliferation in oral squamous cell carcinoma [J]. Int J Mol Med，2018，41（2）：687-696.
[25] Li X，Xu Q，Wu YH，et al. A CCL2/ROS autoregulation loop is critical for cancer-associated fibroblasts-enhanced tumor growth of oral squamous cell carcinoma [J].Carcinogenesis，2014，35（6）：1362-1370.
[26] Qin X，Yan M，Wang X，et al. Cancer-associated Fibroblast-derived IL-6 Promotes Head and Neck Cancer Progression via the Osteopontin-NF-kappa B Signaling Pathway [J]. Theranostics，2018，8（4）：921-940.
[27] Zhou B，Chen WL，Wang YY，et al. A role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma [J]. J Oral Pathol Med，2014，43（8）：585-592.
[28] Faber A，Goessler UR，Hoermann K，et al. SDF-1-CXCR4 axis：Cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinoma [J]. Oncol Rep，2013，29（6）：2325-2331.
[29] Koontongkaew S，Amornphimoltham P，Monthanpisut P，et al. Fibroblasts and extracellular matrix differently modulate MMP activation by primary and metastatic head and neck cancer cells [J]. Med Oncol，2012，29（2）：690-703.
[30] Hannafon BN，Ding WQ. Intercellular Communication by Exosome-Derived microRNAs in Cancer [J]. Int J Mol Sci，2013，14（7）：14 240-14 269.
[31] Tkach M，Thery C. Communication by Extracellular Vesicles：Where We Are and Where We Need to Go [J]. Cell，2016，164（6）：1226-1232.
[32] Vader P，Breakefield XO，Wood MJA. Extracellular vesicles：emerging targets for cancer therapy [J]. Trends Mol Med，2014，20（7）：385-393.
[33] Chen SF，Nieh S，Jao SW，et al. The paracrine effect of cancer-associated fibroblast-induced interleukin-33 regulates the invasiveness of head and neck squamous cell carcinoma [J]. J Pathol，2013，231（2）：180-189.
[34] Sobral LM，Bufalino A，Lopes MA，et al. Myofibroblasts in the stroma of oral cancer promote tumorigenesis via secretion of activin A [J]. Oral Oncol，2011，47（9）：840-846.
[35] Bagordakis E，Sawazaki-Calone I，Macedo CC，et al. Secretome profiling of oral squamous cell carcinoma-associated fibroblasts reveals organization and disassembly of extracellular matrix and collagen metabolic process signatures [J]. Tumour Biol，2016，37（7）：9045-9057.
[36] Qin X，Yan M，Zhang J，et al. TGF beta 3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis [J]. Sci Rep，2016，6：20 587.
[37] Takahashi H，Sakakura K，Kudo T，et al. Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages [J]. Oncotarget，2017，8（5）：8633-8647.
[38] Takahashi H，Sakakura K，Kawabata-Iwakawa R，et al. Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma [J]. Cancer Immunol Immunother，2015，64（11）：1407-1417.