长链非编码RNA在原发性肝癌中的研究进展

Abstract
Figure/Table
References (27)
Related Citation (15)

Download: PDF (672 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Hepatocellular carcinoma (HCC) is the most common primary liver cancer in clinic. The prevalence of HCC in China is higher around the world. HCC is highly malignant, difficult to treat, prone to recurrence, with poor prognosis. Therefore, more and more studies focus on finding new molecular markers for the diagnosis, treatment and prognosis evaluation of HCC. Long noncoding RNA (lncRNA) is one of the non-coding RNA. The imbalanced expression of lncRNA acts as oncogene or tumor suppressor gene and participates in the occurrence and development of malignant tumors. Recent studies have found that the imbalance of lncRNA expression is involved in many biological processes of HCC. This paper mainly summarizes recent studies on the role of lncRNA in the occurrence and development of HCC tumors, and provides theoretical basis for the use of lncRNA in the diagnosis, prognosis or treatment of HCC.

Key words： Long noncoding RNA Primary liver cancer Molecular markers Research progress

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YIN Hongzhen1* GUO Hualei1* PEI Ying1 CHAO Xu2 HUANG Feng3

Cite this article:

YIN Hongzhen1* GUO Hualei1* PEI Ying1 CHAO Xu2 HUANG Feng3. Research progress of long noncoding RNA in primary liver cancer[J]. 中国医药导报, 2019, 16(20): 34-37,48.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I20/34

[1] 李照，朱继业.《原发性肝癌诊疗规范（2017年版）》解读[J].临床肝胆病杂志，2017，33（9）：1655-1657.
[2] Chen W，Zheng R，Baade PD，et al. Cancer statistics in China，2015 [J]. CA Cancer J Clin，2016，66（2）：115-132.
[3] Li C，Chen J，Zhang K，et al. Progress and Prospects of Long Noncoding RNAs（lncRNAs）in Hepatocellular Carcinoma [J]. Cell Physiol Biochem，2015，36（2）：423-434.
[4] Shi X，Sun M，Wu Y，et al. Post-transcriptional regulation of long noncoding RNAs in cancer [J]. Tumor Biol，2015， 36（2）：503-513.
[5] Luo J，Qu J，Wu DK，et al. Long non-coding RNAs：a rising biotarget in colorectal cancer [J]. Oncotarget，2017，8（13）：22187-22202.
[6] Jin T，Wu X，Yang H，et al. Association of the miR-17-5p variants with susceptibility to cervical cancer in a Chinese population [J]. Oncotarget，2016，7（47）：76647-76655.
[7] Takahashi K，Yan IK，Haga H，et al. Modulation of hypoxia-signaling pathways by extracellular linc-RoR [J]. J Cell Sci，2014，127（7）：1585-1594.
[8] Yang L，Lin C，Jin C，et al. LncRNA-Dependent Mechanisms of Androgen Receptor-regulated Gene Activation Programs [J]. Nature，2013，500（7464）：598-602.
[9] Xiang JF，Yin QF，Chen T，et al. Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus [J]. Cell Res，2014， 24（9）：1150.
[10] 王海博，李忠廉.lncRNA UCA1在肝癌中的表达及对肝癌HepG2细胞增殖和侵袭的作用及机制[J].天津医药，2018，46（7）：682-686.
[11] Xiao JN，Yan TH，Yu RM，et al. Long non-coding RNA UCA1 regulates the expression of Snail2 by miR-203 to promote hepatocellular carcinoma progression [J]. J Cancer Res Clin Oncol，2017，143（6）：981-990.
[12] Liu Z，Wei X，Zhang A，et al. Long non-coding RNA HNF1A-AS1 functioned as an oncogene and autophagy promoter in hepatocellular carcinoma through sponging hsa-miR-30b-5p [J]. Biochem Biophys Res Commun，2016，473（4）：1268-1275.
[13] Hu P，Yang J，Hou Y，et al. LncRNA expression signatures of twist-induced epithelial-to-mesenchymal transition in MCF10A cells [J]. Cell Signal，2014，26（1）：83-93.
[14] Chen Z，Zhou ZY，He CC，et al. Down-regulation of LncRNA NR027113 inhibits cell proliferation and metastasis via PTEN/PI3K/AKT signaling pathway in hepatocellular carcinoma [J]. Eur Rev Med Pharmacol Sci，2018，22（21）：7222-7232.
[15] Chen G，Wang Z，Wang D，et al. LncRNA Disease：a database for long-non-coding RNA-associated diseases [J]. Nucleic Acids Res，2013，41（Database issue）：D983-D986.
[16] Palmieri G，Paliogiannis P，Sini MC，et al. Long non-coding RNA CASC2 in human cancer [J]. Crit Rev Oncol Hematol，2017，111：31-38.
[17] Pu XH，Li F，Miao XL，et al. Transforming growth factor beta regulates hepatic progenitor cells migration via PI3K/AKT/mTOR/p70S6K pathway [J]. Zhonghua Gan Zang Bing Za Zhi，2018，26（9）：680-685.
[18] Wei C，Jia Y，Qi Z，et al. Downregulation of lncRNA OG-FRP1 inhibits hepatocellular carcinoma progression by AKT/mTOR and Wnt/β-catenin signaling pathways [J]. Cancer Manag Res，2018，10：1817-1826.
[19] Sun QM，Hu B，Fu PY，et al. Long non-coding RNA 00607 as a tumor suppressor by modulating NF-κB p65/p53 signaling axis in hepatocellular carcinoma [J]. Carcinogenesis，2018，39（12）：1438-1446.
[20] 蔡民，许浏，沈兰，等.长链非编码RNA FOXN3-AS2在肝癌中的表达及其对肝癌细胞增殖和侵袭的影响[J].中国临床药理学与治疗学，2018，23（11）：52-57.
[21] Zhang J，Li Z，Liu L，et al. Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway [J]. Hepatology，2018，67（1）：171-187.
[22] Wang Y，Jing W，Ma W，et al. Down-regulation of long non-coding RNA GAS5-AS1 and its prognostic and diagnostic significance in hepatocellular carcinoma [J]. Cancer Biomark，2018，22（2）：227-236.
[23] 蔡杰，林孔英，袁声贤，等.长链非编码RNA AK125512在肝癌组织中的表达及其临床意义[J].肝胆胰外科杂志，2016，28（2）：93-97.
[24] Yang Z，Zhou L，Wu LM，et al. Overexpression of Long Non-coding RNA HOTAIR Predicts Tumor Recurrence in Hepatocellular Carcinoma Patients Following Liver Transplantation [J]. Ann Surg Oncol，2011，18（5）：1243-1250.
[25] Zijun X，Fangyuan Z，Yidong Y，et al. Lnc-PCDH9-13：1 Is a Hypersensitive and Specific Biomarker for Early Hepatocellular Carcinoma [J]. EBioMedicine，2018，33：57-67.
[26] Sun J，Wei X，Xu L. Upregulation of lncRNA Sox2ot indicates a poor prognosis for patients with hepatocellular carcinoma and promotes cell invasion [J]. Oncol Lett，2018，16（1）：1189-1195.
[27] Zhang J，Zhang D，Zhao Q，et al. A distinctively expressed long noncodingRNA，RP11-466I1.1，may serve as a prognostic biomarker in hepatocellular carcinoma [J]. Cancer Med，2018，7（7）：2960-2968.