阿莫西林不同给药方案对根除幽门螺杆菌疗效的影响

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Abstract Objective To observe the clinical efficacy of Amoxicillin in different dosage regimen on Helicobacter pylori (Hp) eradication. Methods From April 2016 to January 2017, 210 cases of Hp infection in the outpatient department of Liuzhou People′s Hospital of Guangxi Zhuang Autonomous Region were divided into two dosing group, three dosing group and four dosing group in accordance with the random number table with 70 cases in each group. Each group was given Raberazole, Clasamycin, Colloidal bismuth pectin, and Amoxicillin 1 g was given twice-daily to two dosing group, Amoxicillin 500 mg was given three times-daily to three dosing group and four times-daily to four dosing group. Hp was examined at 4 weeks after completing treatment. The eradication rate of Hp, the incidence of adverse drug reactions and the compliance of each group were compared. Results The eradication rate of Hp in two-dose group and three-dose group was significantly lower than that in four-dose group, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions and medication compliance among groups (P ＞ 0.05). Conclusion Amoxicillin four times daily dosing can significantly improve the eradication rates of Hp.

Key words： Amoxicillin Raberazole Clasamycin Colloidal bismuth pectin Helicobacter pylori

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	LUO Yihui1 LIU Daihua2

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LUO Yihui1 LIU Daihua2. Efficacy of Amoxicillin in different dosage regimen on Helicobacter pylori eradication[J]. 中国医药导报, 2019, 16(19): 148-151.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I19/148

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