|
|
Effects of two kinds of intraspinal block anesthesia on body temperature during different periods of labor in patients with latent labor analgesia |
ZHANG Fujie MENG Fanhao▲ ZHAO Fuhua JI Yunzhao |
Department of Anesthesiology, Hebei Petroleum Central Hospital, Hebei Province, Langfang 065000, China |
|
|
Abstract Objective To compare the effects of two kinds of intraspinal block anesthesia on body temperature during different periods of labor in patients with latent labor analgesia. Methods From June 2017 to July 2018, 240 eligible pregnant who was the first-time mothers in Heibei Petroleum Center Hospital were selected, according to the random number table method, they were randomly divided into continuous epidural block and analgesia group (group A), combined lumbar stiffness block and analgesia group (group B) and no labor analgesia group (group C), 80 cases in each group. Patients in group A were given continuous epidural block anesthesia when the uterine opening was 1-2 cm, and 0.1% Ropivacaine Hydrochloride was given 8 mL. After 30 min, the epidural catheter was connected with the automatic electronic analgesic pump (the electronic pump was equipped with 0.1% Ropivacaine Hydrochloride and 0.5 μg/mL mixed solution of Sufentanil 100 mL). Patients in group B were treated with lumbar hard combined block anesthesia when the uterine opening was 1-2 cm, followed by subarachnoid injection of 0.1% Ropivacaine 3 mg. After 30 minutes, the epidural catheter was connected with the automatic electronic pump. Group C was in normal delivery. Withdrawing the labor analgesia when the delivery was ending. The maternal temperature was measured at the time of delivery, the temperature at 2 cm of the uterine opening, the temperature at 4 cm of the uterine opening, the temperature at the full time of the uterine opening, and the temperature at 2 h and 24 h after the delivery in three groups. All parturients were tested for CRP and WBC by venous blood sampling before and after 24 h. Results The fever rate of >37.3℃ in group A and group B was significantly higher than that in group C, and the difference was statistically significant (P < 0.05). Postpartum CRP levels of three groups were higher than those of prenatal women, and the levels of postpartum CRP in group A and group B were higher than those in group C, the differences were statistically significant (P < 0.05). Conclusion Both kinds of intraspinal anesthesia can cause the rise of body temperature during childbirth, but it can return to normal 24 h after delivery. The increase of body temperature has little relationship with infection.
|
|
|
|
|
[1] Tian F,Wang K,Hu J,et al. Continuous spinal anesthesia with sufentanil in labor analgesia can induce maternal febrile responses in puerperas [J]. Int J Clin Exp Med,2013, 6(5):334-341.
[2] Chen SY,Lin PL,Yang YH,et al. The effects of different epidural analgesia formulas on labor and mode of delivery in nulliparous women [J]. Taiwan J Obstet Gynecol,2014, 53(1):8-11.
[3] 甘果,李诚,袁力勇,等.瑞芬太尼病人静脉自控镇痛用于分娩镇痛[J].医学研究杂志,2011,40(9):87-91.
[4] 薛璇,侯雯雯,贾瑞喆,等.硬膜外分娩镇痛下产间发热临床分析[J].南京医科大学学报:自然科学版,2013(12):1763-1765.
[5] Mantha VR,Vallejo MC,Ramesh V,et al. Maternal and cord serum cytokine changes with continuous and intermittent labor epidural analgesia:a randomized study [J]. Scientific World J,2012,2012:607938.
[6] Riley LE,Celi AC,Onderdonk AB,et al. Association of epidural-related fever and noninfectious inflammation in term labor [J]. Obstet Gynecol,2011,117(3):588-595.
[7] de Orange FA,Passini RJ,Amorim MM,et al. Combined spinal and epidural anaesthesia and maternal intrapartum temperature during vaginal delivery:a randomized clinical trial [J]. Br J Anaesth,2011,107(5):762-768.
[8] Irestedt L. The rise in maternal temperature associated with regional analgesia in labour is harmful and should be treated [J]. Int J Obstet Anesth,2003,12(4):284-286.
[9] 冯艳,张广兰.硬膜外分娩镇痛与产时发热的关系[J].中华围产医学杂志,2012,15(6):368-370.
[10] Baker A,Meert T. Morphine and D-amphetamine nullify each others′ hypothermic effects in mice [J]. Pharmacol Toxicol,2003,92(2):64-70.
[11] Goetzl L,Evans T,Rivers J,et al. Elevated maternal and fetal serum interleukin-6 levels are associated with epidural fever [J]. Am J Obstet Gynecol,2002,187(4):834-838.
[12] Baker AK,Meert TF. Functional effects of systemically administered agonists and antagonists of mu,delta,and kappa opioid receptor subtypes on body temperature in mice [J]. J Pharmacol Exp Ther,2002,302(3):1253-1264.
[13] de Orange FA,Passini RJ,Amorim MM,et al. Combined spinal and epidural anaesthesia and maternal intrapartum temperature during vaginal delivery:a randomized clinical trial [J]. Br J Anaesth,2011,107(5):762-768.
[14] Salmi P,Kela J,Arvidsson U,et al. Functional interactions between delta- and mu-opioid receptors in rat thermoregulation [J]. Eur J Pharmacol,2003,458(1-2):101-106.
[15] Sevarino FB,Johnson MD,Lema MJ,et al. The effect of epidural sufentanil on shivering and body temperature in the parturient [J]. Anesth Analg,1989,68(4):530-533.
[16] Romanovsky AA. Thermoregulation:some concepts have changed. Functional architecture of the thermoregulatory system [J]. Am J Physiol Regul Integr Comp Physiol,2007,292(1):R37-R46.
[17] Anim-Somuah M,Smyth RM,Cyna AM,et al. Epidural versus non-epidural or no analgesia for pain management in labour [J]. Cochrane Database Syst Rev,2018, 5:D331.
[18] Dashe JS,Rogers BB,McIntire DD,et al. Epidural analgesia and intrapartum fever:placental findings [J]. Obstet Gynecol,1999,93(3):341-344.
[19] Sharma SK,Rogers BB,Alexander JM,et al. A randomized trial of the effects of antibiotic prophylaxis on epidural-related fever in labor [J]. Anesth Analg,2014, 118(3):604-610. |
|
|
|