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| Relationship between serum 25-(OH)D3 level and bone mineral density in patients with rheumatoid arthritis |
| ZOU Jinmei LI Siyin YANG Jing LI Min |
| Department of Rheumatology and Immunology, Mianyang Central Hospital, Sichuan Province, Mianyang 621000, China |
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Abstract Objective To study the relationship between serum 25-hydroxyvitamin D3[25-（OH）D3] level and bone mineral density in patients with rheumatoid arthritis (RA). Methods A total of 512 cases of patients with RA admitted to Mianyang Central Hospital of Sichuan Province (“our hospital” for short) from February 2016 to February 2018 were selected as the study group. Another 80 healthy people who underwent physical examination in our hospital at the same time were used as a control group. Serum 25-(OH)D3 levels, bone mineral density, and bone mineral density T values were measured in both groups. According to the X-ray staging criteria of American Rheumatism Society, the study group was divided into 128 cases in stage Ⅰ, 162 cases in stage Ⅱ, 133 cases in stage Ⅲ and 89 cases in stage Ⅳ, and compared serum 25-(OH)D3 and bone of patients with different stages of RA. According to the different levels of serum 25-(OH)D3 deficiency, the study group was divided into 130 cases of serum 25-(OH)D3 deficiency, 168 cases of mild deficiency, 127 cases of moderate deficiency and 87 cases of severe deficiency. The bone mineral density and bone mineral density T values were compared, and the correlation between serum 25-(OH)D3 and bone mineral density and bone mineral density T values in RA patients was analyzed. Results Serum 25-(OH)D3, bone mineral density and bone mineral density T values in the study group were lower than those in the control group (all P < 0.01). Serum 25-(OH)D3, bone mineral density and bone mineral density T values in patients with stage Ⅰ-Ⅳ RA showed a gradual downward trend, with highly statistical significance (all P < 0.01). Bone mineral density and bone mineral density T value of RA patients with serum 25-(OH) D3 deficiency, mild deficiency, moderate deficiency and severe deficiency showed a decreasing trend, with highly statistical significance (all P < 0.01). Pearson correlation analysis showed that serum 25-(OH)D3 was positively correlated with bone mineral density and bone mineral density T value in RA patients (r = 0.523, 0.584, all P < 0.05). Conclusion Serum 25-(OH)D3 level and bone mineral density in RA patients are significantly decreased, and there is a significant positive correlation between them. That is, bone mineral density decreases with the increasing lack of serum 25-(OH)D3 level.
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