曲妥珠单抗联合GEM、CAP化疗对HER-2阳性晚期乳腺癌患者血清T细胞亚群、TPS水平及生存质量的影响

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Abstract Objective To investigate the effect of Trastuzumab combined with Gemcitabine (GEM) and Capecitabine (CAP) in advanced breast cancer patients with positive human epidermal growth factor receptor 2 (HER-2). Methods Eighty patients with HER-2 positive advanced breast cancer admitted to the Affiliated Hospital of Armed Police Logistics College from August 2010 to April 2015 were selected. According to the random number table, 40 cases in control group were treated with GEM and CAP, and 40 cases in observation group were treated with Trastuzumab on the basis of control group. The disease control and the levels of serum tumor markers indicators [tissue polypeptide specific antigen (TPS), cancer-related glycoprotein antigen 153 (CA153)] before and after treatment, serum T cell subsets (serum CD3+, CD4+, CD8+) levels and quality of life dimensions (role function, emotional function, cognitive function, physical function, social function) score changes were observed between two groups, the occurrence of toxic and side effects and survival rate were also counted between two groups. Results The clinical efficacy of observation group was better than that of control group, and the disease control rate of observation group was higher than that of control group (P < 0.05). After 2 months of treatment, the levels of serum TPS and CA153 in two groups were lower than those before treatment, and the decrease in observation group was more obvious than that in control group (P < 0.05). After 2 months of treatment, the levels of serum CD3+ and CD4+ in two groups were lower than those before treatment, but the levels in observation group were higher than those in control group (P < 0.05). There was no significant difference in serum CD8+ level between two groups before and after treatment (P ＞ 0.05). There was no significant difference in the incidence of leukopenia, nausea, vomiting and thrombocytopenia between two groups (P ＞ 0.05). The scores of cognitive function, somatic function, role function, emotional function and social function in two groups were higher than those before treatment, and those in observation group were higher than those in control group (P < 0.05). There was no significant difference in 1, 2 and 3-year survival rates between two groups (P ＞ 0.05). Conclusion Trastuzumab combined with GEM and CAP chemotherapy can reduce serum tumor marker levels in patients with HER-2 positive advanced breast cancer, improve the clinical control rate of the disease, have less damage to the patient′s immune function and have a high prognosis survival rate with fewer side effects. It can improve the quality of life of patients.

Key words： Advanced breast cancer HER-2 positive Trastuzumab GEM CAP Serum T cell subset TPS level Quality of life

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	SHEN Chunyan1 JIN Xiaoxin1 WANG Shuling2

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SHEN Chunyan1 JIN Xiaoxin1 WANG Shuling2. Effect of Trastuzumab combined with GEM and CAP chemotherapy on serum T cell subsets, TPS levels and quality of life in patients with HER-2 positive advanced breast cancer[J]. 中国医药导报, 2019, 16(19): 93-97.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I19/93

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