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| Literature research on TCM medication law of HBV-related hepatocirrhosis |
| YANG Xianzhao1,2 JIANG Feng2,3 RU Shuying2,4 ZHANG Peng2,3 LI Ying2,3 ZHANG Ludan2,3 YE Yong′an2,3 |
1.Department of Infectious Disease, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China;
2.Institute of Liver Diseases, Beijing University of Chinese Medicine, Beijing 100700, China;
3.Department of Gastroenterology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China;
4.Department of Gastroenterology, Dongzhimen Hospital Eastern Affiliated to Beijing University of Chinese Medicine, Beijing 101100, China |
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Abstract Objective To analyze the traditional Chinese medicine (TCM) medication law of HBV-related hepatocirrhosis based on the past clinical research literatures. Methods The clinical research literatures on TCM for HBV-related hepatocirrhosis from inception to September 2016 was searched in PubMed, Chinese biomedical literature database (CBM), China National Knowledge Infrastructure (CNKI), WanFang Data, VIP network. A database of TCM decoctions for HBV-related hepatocirrhosis was established. The frequency of medication was analyzed. The effect, nature and flavor of herbs were descriptively analyzed. Results A total of 118 articles were included. There were 121 prescriptions, 204 herbs and 1356 herb frequency involved. There were 11 herbs with a frequency greater than 30. The top 5 were Radix Astragali, Radix Salviae Miltiorrhizae, Carapax Trionycis, Rhizoma Atractylodis Macrocephalae and Radix Bupleuri. The 204 herbs could be divided into 19 categories according to the effect. The top 5 were deficiency-supplementing herb, blood-quickening stasis-transforming herb, heat-clearing herb, dampness-removing herb and qi-regulating herb, with a total frequency of 80.23%. In the frequency of herb nature, the top 3 were cold, warm and calm. The total frequency of cold herbs and slightly cold herbs was 37.75%. In the frequency of herb flavor, the top 3 were bitter, sweet and pungent. The frequency of bitter herbs was 32.40%. Conclusion The general rule of TCM in the treatment of HBV-related hepatocirrhosis is strengthening the body resistance and eliminating pathogenic factors. In the specific principle, on the basis of qi-boosting spleen-supplementing yin-nourishing therapy, blood-quickening stasis-transforming therapy, heat-clearing toxin-resolving therapy, dampness-clearing therapy and liver-coursing qi-rectifying therapy are often used in treating HBV-related hepatocirrhosis.
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