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| Effect of Shenqi Fuzheng Injection combined with Simvastatin in the treatment of sepsis and its influence on vascular endothelial function |
| XUE Yulin1 WANG Yujuan2 |
1.Department of General Medicine, Xinjiang Cardiovascular Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830011, China;
2.Department of Cardiology, Xinjiang Cardiovascular Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830011, China |
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Abstract Objective To investigate the effect of Shenqi Fuzheng Injection combined with Simvastatin in the treatment of sepsis and its influence on vascular endothelial function. Methods The clinical data of 92 patients with sepsis admitted to Xinjiang Cardiovascular Hospital from January to December 2016 was analyzed retrospectively, and the patients were divided into control group (46 cases) and observation group (46 cases) according to different treating methods. On basis of conventional treatment, the control group was given Simvastatin, while the observation group was treated with adjuvant therapy of Shenqi Fuzheng Injection based on the treatment of control group. The clinical efficacy, the scores of acute physiology and chronic health evaluation scoring system (APACHEⅡ) and sequential organ failure assessment (SOFA), and the vascular endothelial function of the two groups were compared. Results After treatment, the total effective rate of observation group was statistically significantly higher than that of the control group (89.1% vs 71.7%, P ＜ 0.05). After treatment, the scores of APACHEⅡ and SOFA in the two groups were all lower than those before treatment (all P ＜ 0.05), and the scores of APACHEⅡ and SOFA in the observation group after treatment were all lower than those of the control group, the differences were all statistically significant (all P ＜ 0.05). The indexes of vascular endothelial function showed that the levels of endothelin-1 (ET-1) after treatment in the two groups were all lower than those before treatment, the levels of nitric oxide (NO) after treatment in the two groups were all higher than those before treatment (all P ＜ 0.05), and the levels of ET-1 after treatment in the observation group were lower than those of control group, the levels of NO after treatment in the observation group were higher than those of control group (all P ＜ 0.05). Conclusion Application of Shenqi Fuzheng Injection combined with Simvastatin in sepsis has good effects, which can increase the clinical efficacy, relieve the clinical symptoms and improve the vascular endothelial function, it is worthy of clinical application.
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