丁苯酞联合前列地尔注射液治疗后循环缺血性眩晕的临床效果

Abstract
Figure/Table
References (23)
Related Citation (10)

Download: PDF (506 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the curative efficacy of Butylphthalide in combination with Alprostadil Injection in patients with posterior circulation ischemic vertigo. Methods One hundred and ten patients with posterior circulation ischemic vertigo who received therapy in Huangshi Central Hospital of Edong Healthcare Group from January to October 2016 were collected as observational objects and randomly divided into the control group (55 cases) and the observation group (55 cases) according to random number table. Besides conventional treatment, the control group was treated with Alprostadil Injection, while the observation group was treated with Butylphthalide in combination with Alprostadil Injection. After treatment of 2 weeks, the curative efficacy, blood velocity of posterior circulation before and after treatment and adverse reactions were compared. Results Assessment of curative efficacy of vertigo showed that the total effective rate in the observation group was statistically higher than that in the control group (94.5% vs 81.8%, P ＜ 0.05). Before treatment, there were no significant differences of blood velocity of basilar artery, left vertebral artery and right vertebral artery between the two groups (P ＞ 0.05). After treatment, the indexes above in the two groups were all significantly faster than those before treatment (all P ＜ 0.05), and blood velocity of basilar artery, left vertebral artery and right vertebral artery in the observation group was higher than those of control group (all P ＜ 0.05). During the treatment, there was no case with severe adverse reactions, and the incidence of adverse reactions in the control group and the observation group had no statistically significant difference (5.4% vs 7.3%, P ＞ 0.05). Conclusion Butylphthalide in combination with Alprostadil Injection is effective for patients with posterior circulation ischemic vertigo, which can improve the curative efficacy, speed up the blood velocity of posterior circulation, with low incidence of adverse reactions, it is worthy of clinical application.

Key words： Butylphthalide Alprostadil Injection Posterior circulation ischemic vertigo Blood velocity

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIU Yafang1
	2 HUANG Yongmei3▲ DAI Jun1 CAO Xiongbin1
	2 SHI Yunqiong1

Cite this article:

LIU Yafang1,2 HUANG Yongmei3▲ DAI Jun1 CAO Xiongbin1,2 SHI Yunqiong1. Clinical efficacy of Butylphthalide in combination with Alprostadil Injection in the treatment of posterior circulation ischemic vertigo[J]. 中国医药导报, 2017, 14(18): 145-148.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I18/145

[1] 李志军，唐娜.尼麦角林治疗后循环缺血性眩晕的疗效观察[J].中华老年医学杂志，2013，32（3）：291-295.
[2] 林彬，陶杨，王东宁，等.CT、MRI和磁共振动脉成像对后循环缺血性眩晕的诊断价值[J].中国医学创新，2015， 12（18）：64-65.
[3] 王媛，贾建平，孙永馨，等.后循环缺血性单发性眩晕的研究进展[J].临床神经病学杂志，2011，24（4）：311-312.
[4] 国家中医药管理局.中华人民共和国中医药行业标准·中医病证诊断疗效标准[S].1994.
[5] 冯家银.中药药氧联合丁咯地尔对后循环缺血性眩晕的疗效观察[J].中国实用神经疾病杂志，2016，19（15）：104-105.
[6] 于峰.氟桂利嗪联合银杏达莫治疗老年后循环缺血性眩晕的疗效[J].中国老年学杂志，2012，32（6）：1172-1173.
[7] Wen Y，Zhang C，Zhao XF，et al. Safety of different acupuncture manipulations for posterior circulation ischemia with vertigo [J]. Neural Regen Res，2016，11（8）：1267-1273.
[8] 李新萍，冯彦敏.前列地尔注射液治疗椎-基底动脉供血不足所致眩晕的疗效观察[J].山东医药，2009，49（33）：10.
[9] Deng SZ，Zhao XF，Huang LH，et al. The quantity-effect relationship and physiological mechanisms of different acupuncture manipulations on posterior circulation ischemia with vertigo：study protocol for a randomized controlled trial [J]. Trials，2015，16：152.
[10] 于明，张凯博.前列地尔合并丹红注射液治疗老年椎-基底动脉系统短暂性脑缺血所致眩晕的疗效观察[J].解放军药学学报，2010，26（3）：270-271.
[11] 魏薇，袁红，冯媛媛，等.前列地尔治疗糖尿病周围神经病变临床观察[J].中国医药导报，2012，9（12）：76-77.
[12] 尹春丽，李永秋，王耀伍，等.丁苯酞软胶囊对急性脑梗死缺血半暗带的影响[J].临床神经病学杂志，2013，26（3）：219-221.
[13] 朱远群，谭双全，阮海林，等.丁苯酞软胶囊联合依达拉奉治疗急性脑梗死的疗效分析[J].广东医学，2010，31（12）：1607-1609.
[14] Lawall H，Pokrovsky A，Checinski P，et al. Efficacy and Safety of Alprostadil in Patients with Peripheral Arterial Occlusive Disease Fontaine Stage Ⅳ：Results of a Placebo Controlled Randomised Multicentre Trial（ESPECIAL）[J]. Eur J Vasc Endovasc Surg，2017，53（4）：559-566.
[15] 奚继明，张江涛，杜海松，等.丁苯酞联合依达拉奉治疗急性脑梗死临床观察[J].中国医药导报，2011，8（11）：73-75.
[16] 范秀玉，范博，吴铁丽，等.经颅多普勒联合脑干听觉诱发电位对后循环缺血的诊断价值[J].中国全科医学，2011， 14（30）：3516-3517.
[17] 陈惠灵，何艳，崔穗晶，等.脑梗死患者颅内侧支循环与预后的关系探讨[J].中国医药导报，2012，9（14）：186-187，190.
[18] Sloan MA，Alexandrov AV，Tegeler CH，et al. Assessment：transcranial Doppler ultrasonograpy：report of the Therapeutic and Technology Assessment Subcommittee of the American Academy of Neuroly [J]. Neurology，2004，62（9）：1468-1481.
[19] 王鸿波，李岩，裴俏，等.基于经颅多普勒超声（TCD）评价加味半夏白术天麻汤对后循环缺血性眩晕临床疗效[J].中医药信息，2014，31（4）：149-150.
[20] 沈勤康，严民力，戚观树，等.补阳还五汤加减治疗后循环缺血性眩晕的临床观察[J].中国现代医生，2016，54（21）：135-138.
[21] 胡运新，潘梦秋.丁苯酞软胶囊治疗脑小血管病伴发非痴呆血管性认知功能损害患者的临床研究[J].现代医院，2015，15（12）：50-52.
[22] Abdoulaye IA，Guo YJ. A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives [J]. Biomed Res Int，2016，2016：5012341.
[23] Xue LX，Zhang T，Zhao YW，et al. Efficacy and safety comparison of DL-3-n-butylphthalide and Cerebrolysin：Effects on neurological and behavioral outcomes in acute ischemic stroke [J]. Exp Ther Med，2016，11（5）：2015-2020.