高危HPV检测联合液基细胞学检查在妊娠期妇女宫颈疾病筛查中的价值

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Abstract Objective To investigate the necessity of routine screening of cervical diseases during pregnancy through the high-risk HPV detection combined with TCT examination. Methods From January 2013 to December 2015, in outpatinet of Obstetrics, Shanghai Tongren Hospital, 7316 pregnant women received the high-risk HPV detection and TCT examination in the first prenatal examination were selected. Pregnant women with high-risk HPV positive or abnormal TCT results received the colposcopy assessment, and those abnormal women further received the microscopic histological biopsy. Results In 7316 pregnant women, there were 584 high-risk HPV positive pregnant women, accounting for 7.98%, and 180 pregnant women with abnormal TCT examination, accounting for 2.46%. The sensitivity, specificity, positive predictive value and negative predictive value of high-risk HPV detection for cervical lesions was 91.40%, 93.09%, 14.55% and 99.88%, respectively, those of TCT examination was 86.02%, 98.62%, 44.44% and 99.82%, respectively, and those of high-risk HPV detection combined with TCT examination was 100.00%, 92.55%, 14.74% and 100.00%, respectively. There was no significant correlation between HPV load and severity of cervical lesions (P > 0.05). Conclusion In terms of cervical disease screening for pregnant women, the high-risk HPV detection combined with TCT examination has a higher sensitivity and negative predictive value than that of single application of HPV detection and TCT examination, which can find the cervical lesions timely, so that the disease can be detected and treated early.

Key words： Combined screening Pregnacy Human papilloma virus Liquid-based thin-layer cervical cytology Cervical diseases

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NI Qian ZHOU Yuehua NI Yunxiang▲. Value of high risk HPV combined liquid-based cytology testing in screening cervical disease in pregnancy women[J]. 中国医药导报, 2017, 14(18): 109-112.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I18/109

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