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Research progress on the pathogenesis and TCM therapy of coagulation disorders in sepsis |
XU Zhibing1 SONG Li1 ZHAO Wairong2 |
1.Department of Emergency, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China;
2.Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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Abstract Sepsis is life-threatening organ dysfunction caused by a deregulated host response to infection, which is critical and can develop into septic shock. There is an inseparable relationship between coagulation disorders and the degree of disease severity and prognosis in patients with sepsis, coagulation disorders runs through the whole pathological process of sepsis. This article mainly reviews the pathogenesis and TCM therapy of coagulation disorders in sepsis, so as to provide new ideas and methods for treating sepsis in clinic.
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[1] Singer M,Deutschman CS,Seymour CW,et al. The Third International Consensus definitions for Sepsis and Septic Shock [J]. JAMA,2016,315(8):801-810.
[2] 郭清华,史春芝,王助衡,等.凝血功能紊乱与脓毒症严重程度及预后的相关性研究[J].医学临床研究,2015,32(2):335-337.
[3] Yao YM,Luan YY,Zhang QH,et al. Pathophysiological aspects of sepsis:an overview [J]. Methods Mol Biol,2015,1237:5-15.
[4] 马晓春.加强对获得性凝血病的认识[J].中国实用外科杂志,2012,32(11):885-886.
[5] Levi M,Schultz M,van der Poll T. Sepsis and thrombosis [J]. Semin Thromb Hemost,2013,39(5):559-566.
[6] 章志丹.严重脓毒症致凝血功能障碍的新认识[J].中国实用外科杂志,2012,32(11):891-894.
[7] 张卉,童亚林,姚咏明.脓毒症凝血功能紊乱的治疗策略[J].临床急诊杂志,2016,17(8):577-580.
[8] 李鑫,马晓春.脓毒症疗程中的抗凝治疗[J].中国实用内科杂志,2015,35(11):897-899.
[9] Rhodes A,Evans LE,Alhazzani W,et al. Surviving Sepsis Campaign:International Guidelines for Management of Sepsis and Septic Shock:2016 [J]. Intensive Care Med,2017, 43(3):304-377.
[10] Liu XL,Wang XZ,Liu XX,et al. Low-dose heparin as treatment for early disseminated intravascular coagulation during sepsis:A prospective clinical study [J]. Exp Ther Med,2014,7(3):604-608.
[11] 刘志永,朱红,马晓春.肝素治疗脓毒症的系统评价[J].中华危重病急救医学,2014,26(3):135-141.
[12] 王庆,赖国祥,吴文燕.中西医对脓毒症发病机制的研究进展[J].现代中西医结合杂志,2007,16(20):2940-2942.
[13] 中国中西医结合学会急救医学专业委员会.脓毒症中西医结合诊治专家共识[J].中华危重病急救医学,2013, 25(4):194-197.
[14] 刘清泉.对脓毒症中医病机特点及治法的认识[J].北京中医药,2007,26(4):198-200.
[15] 唐彬,李云华,彭映辉,等.赵淳教授中西医结合救治脓毒症学术经验[J].中国中医急症,2010,19(6):984-985.
[16] 洪峰,俞兴群.脓毒症凝血功能障碍的中西医研究进展[J].中医药临床杂志,2014,26(8):864-866.
[17] 王今达,李志军,李银平.从“三证三法”辨证论治脓毒症[J].中国危重病急救医学,2006,18(11):643-644.
[18] 高风江,任何菊,张玮曾,等.血必净注射液对创伤性脓毒症患者血清降钙素原、全血细胞计数及脏器功能评分的影响[J].临床合理用药杂志,2015,8(4A):104-105.
[19] 孙红双,吕菁君,魏捷.血必净注射液对脓毒症患者凝血功能影响分析[J].临床药物治疗杂志,2015,13(4):41-46.
[20] 张雷.益气扶正法对脓毒症患者炎症反应及凝血功能的影响[J].陕西中医,2016,37(10):1381-1382.
[21] 李志云,杜仲平,王春雨,等.丹红注射液对严重脓毒症凝血功能及预后的影响[J].世界中医药,2015,10(8):1197-1200.
[22] 俞林明,明志强,吕银祥,等.大黄对脓毒症患者凝血功能的影响[J].中国中西医结合急救杂志,2006,13(1):48-50.
[23] 吴建浓,朱美飞,雷澍,等.大承气汤对脓毒症患者凝血功能的影响[J].浙江中医药大学学报,2008,32(3):368-369.
[24] 黎永琳,周红,鲍丹艳,等.桃核承气汤对脓毒症大鼠凝血-炎症水平的调控作用研究[J].江西中医药,2015,46(1):35-37.
[25] 傅晓燕,王卫星,张焰理.清瘟败毒饮对脓毒症患者凝血功能的影响[J].安徽中医药大学学报,2009,28(4):30-32.
[26] 郭楠,刘清泉,江其敏,等.血必净与生脉注射液对脓毒症凝血功能障碍影响的临床研究[J].北京中医药,2009, 28(3):182-185. |
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