|
|
|
| Integrated care in the clinical applications of chemotherapy for advanced pancreatic cancer |
| XUE Xiaojing WANG Xiaozhen▲ DUAN Honghong WANG Wei XIE Jin |
| Department of Radiotherapy, Xingtai City People 's Hospital, Hebei Province, Xingtai 054001, China |
|
|
|
|
Abstract Objective To explore and analyze the clinical application of integrated care in the combination of advanced pancreatic cancer radiotherapy. Methods From April 2015 to April 2017, 90 patients with advanced pancreatic cancer underwent three dimensional conformal radiotherapy synchronous chemotherapy treatment in Xingtai City People's Hospital were selected and divided into control group and observation group by random number table, with 45 cases in each group. The control group was treated by the routine care, the observation group was treated by the comprehensive care, they were treated for two months. The adverse reaction, anxiety, depression and quality of life in the groups were compared. Results The observation group had a lower incidence of nausea and vomiting, diarrhea, constipation, liver and kidney dysfunction, abnormal blood picture, hair loss, and stomatitis compared with the control group, with statistically significant difference (P < 0.05). The SAS and SDS scores of the two groups after treatment were decreased than before treatment, the improvement of observation group was more remarkable, with statistically significant difference (P < 0.05). The physical function, role function, emotional function, cognitive function, social function and overall health in the observation group were higher than those in the control group, with statistically significant difference (P < 0.05). Conclusion The application of integrated care in advanced pancreatic cancer with radiotherapy and chemotherapy can reduce the incidence of toxic side effects, improve the anxiety and depression and improve the quality of life.
|
|
|
|
|
|
[1] 李斌.晚期胰腺癌患者应用吉西他滨联合替吉奥治疗的临床效果评价[J].临床和实验医学杂志，2016，15（8）：771-773.
[2] 刘秀娟.晚期胰腺癌区域动脉灌注化疗的临床护理分析[J].齐齐哈尔医学院学报，2015，36（16）：2472-2473.
[3] 郝伟远，俞炎平，王小红，等. CT引导下125I粒子植入联合替吉奥治疗中晚期胰腺癌的临床应用[J].中国现代医生，2015，53（35）：66-69.
[4] 徐继业，徐克友，左彩莹，等.高强度超声聚焦刀联合FOLFOX4方案治疗晚期胰腺癌的临床观察[J].癌症进展，2016，14（4）：381-383.
[5] 卓萌，崔玖洁，王理伟，等.胰腺癌化疗方案的选择及疗效评价[J].临床肝胆病杂志，2017，33（1）：53-56.
[6] 邓颖慧，陈煦婷，王利平. SAS联合SDS量表在湿疹患者焦虑抑郁中的应用研究[J].中国医药科学，2016，6（18）：345-346.
[7] 王建平，陈仲庚，林文娟，等.中国癌症病人生活质量的测定--EORTC QLQ-C30在中国的试用[J].心理学报，2000，32（4）：123-124.
[8] 沈健，张智，庾庆丽，等.卡培他滨联合伊立替康二线治疗晚期胰腺癌的临床研究[J].吉林医学，2013，34（16）：55-56.
[9] 梁宪玲，赵玉沛.家庭健康教育对胰腺癌患者术后生活质量的影响[J].中华全科医学，2013，11（5）：405-406.
[10] 桂毅.胰腺癌患者术后健康知识需求的调查[J].中华现代护理杂志，2012，18（3）：303-305.
[11] 叶瑞繁，耿庆山，陈剑，等. 3种焦虑评定量表在综合医院门诊患者中的应用比较[J].中华行为医学与脑科学杂志，2013，22（3）：271-272.
[12] 李玉，闫英，田启.三维适形放射治疗加动脉化疗胰腺癌的疗效分析[J].中华放射肿瘤学杂志，2012，3（2）：365-368.
[13] 林晓庆.胰腺癌放疗联合替吉奥同步化疗的不良反应观察与护理[J].临床医药文献杂志，2016，3（21）：4215-4216.
[14] 刘纤，任刚，李莉琴，等.胰腺癌TOMO高剂量少分次放射治疗后胃镜下黏膜损伤相关因素研究[J].中国医学装备，2016，13（5）：56-60.
[15] 蔡阳阳，方伟虹.胰腺癌放射治疗的不良反应观察与护理[J].医学信息，2015，28（28）：223-224.
[16] 孙松韦，邹跃，刘家赵，等.局部晚期胰腺癌调强放疗与三维适形放疗剂量学比较及临床疗效分析[J].中华放射医学与防护杂志，2013，33（2）：154-155.
[17] 季洪兵，陈忠华.盐酸吉西他滨联合立体定向放疗治疗局部晚期胰腺癌的效果评价[J].临床肝胆病杂志，2016， 32（3）：537-540.
[18] 刘昌，吕毅，刘原兴，等.DDS区域动脉灌注化疗晚期胰腺癌护理分析[J].肝胆外科杂志，2012，29（23）：31-35.
[19] 王玉民.三维适形放疗联合介入化疗治疗局部晚期胰腺癌的临床效果分析[J].大家健康：下旬版，2016，10（7）：56-57.
[20] 郑红燕.个体化护理对胰腺癌患者负面情绪及生活质量的影响[J].中国农村卫生事业管理，2014，34（7）：871-872. |
|
|
|
