玻璃酸钠关节腔注射对膝骨关节炎患者关节液及血浆中白介素-17的影响

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Abstract Objective To discuss the changes of interleukin-17 (IL-17) levels in both synovial fluid and plasm of patients with primary knee osteoarthritis (OA) after intra-articular injection of Sodium Hyaluronate. Methods 56 patients with primary knee OA given intra-articular injection of Sodium Hyaluronate in Central Hospital of Cangzhou from January 2013 to January 2016 (experimental group) and 30 healthy individuals (control group) were recruited into the study. There were no significant differences in gender, age, and body mass index between the two groups (P > 0.05). Visual analogue scale (VAS) was used to evaluate the pain level of the patients. The IL-17 concentrations in both plasma and synovial fluid were measured before intra-articular injection of Sodium Hyaluronate and at 1, 4, 8, 12 weeks after injection in the experimental group. The IL-17 levels in plasma were measured in the control group. The IL-17 levels were determined using ELISA method. Results Average VAS scores within 8 weeks after the injection were substantially lower than pre-injection periods (P < 0.05) in the experimental group. Average VAS pain score at 12 weeks after intra-articular injection of Sodium Hyaluronate was not statistically significant in comparison with pre-injection period (P > 0.05). Average plasm IL-17 concentration in the control group was (2.4±1.7) pg/mL. OA patients before the injection had higher plasma IL-17 concentration compared to the control group (P < 0.05). Average IL-17 levels in both synovial fluid and plasm at each time point for patients with OA within 8 weeks after the injection were significant lower than pre-injection periods (P < 0.05), but IL-17 levels in plasma were higher than controls (P < 0.05). Average IL-17 levels in both synovial fluid and plasm at 12 weeks after the injection were not statistically significant in comparison with pre-injection periods (P > 0.05). Conclusion For the patients with knee OA, pain symptoms have significantly been improved and IL-17 levels in both synovial fluid and plasm reduced within 8 weeks after intra-articular injection of Sodium Hyaluronate. After 12 weeks, the clinical curative effect has disappearenced, IL-17 levels in both synovial fluid and plasm are restored to the level before treatment.

Key words： Sodium Hyaluronate Osteoarthritis Knee Interleukin-17

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	BAI Yuming1 ZHANG Haisen1 LIU Chang1 JIN Shengli1 SU Ke1 LIU Ying2 LYU Zhichang3

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BAI Yuming1 ZHANG Haisen1 LIU Chang1 JIN Shengli1 SU Ke1 LIU Ying2 LYU Zhichang3. Effect of Sodium Hyaluronate intra-articular injection on both synovial fluid and plasma interleukin-17 of patients with knee osteoarthritis[J]. 中国医药导报, 2017, 14(19): 118-121.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I19/118

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