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| Clinical effect of Bailemian Capsules combined with Escitalopram Tablets in the treatment of insomnia with depression and anxiety |
| ZHANG Dongzi1 CHEN Yalan2 LIU Jiancong3 |
1.Psycho-Counseling Clinics, Affiliated Hospital of Hebei University, Hebei Province, Baoding 071000, China;
2.Department of Digestive Internal Medicine, Affiliated Hospital of Hebei University, Hebei Province, Baoding 071000, China;
3.The Third General Internal Medicine, Hebei Sixth People′s Hospital, Hebei Province, Baoding 071000, China |
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Abstract Objective To investigate the clinical effect of Bailemian Capsules combined with Escitalopram Tablets in the treatment of insomnia with depression and anxiety. Methods From February 2016 to April 2018, 143 cases of insomnia patients with depression and anxiety admitted to the Affiliated Hospital of Hebei University were selected. According to the random number table method, they were divided into the control group (n = 71) and the research group (n = 72). The control group was treated with Escitalopram Tablets, while the research group was treated with Bailemian Capsules on the basis of the control group. The clinical effects of the two groups were compared after 2 months of treatment, compared two groups of patients Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD), Pittsburgh sleep quality index (PSQI), serum neuropeptide Y (NPY) and substance P (SP) were compared before and after 2 months treatment, adverse reactions during treatment were recorded in both groups. Results The total effective rate of the study group was significantly higher than that of the control group (P ＜ 0.05). HAMA, HAMD and PSQI of the two groups were decreased after 2 months of treatment compared with those before treatment, and the study group was lower than the control group (P ＜ 0.05). After 2 months of treatment, the serum NPY level in the two groups was higher than that before treatment, and the level of SP in the study group was lower than that in the control group (P ＜ 0.05). The total incidence of adverse reactions during treatment in the study group was lower than that in the control group (P ＜ 0.05). Conclusion Bailemian Capsules combined with Escitalopram Tablets for the treatment of insomnia with depression and anxiety has an accurate effect, which can effectively improve the clinical symptoms of patients, improve the serum NPY and SP levels of patients, and effectively reduce the incidence of adverse reactions.
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