慢性乙型肝炎病毒感染患者血清IL-33、sST2、MCP-1水平变化及其临床意义

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Abstract Objective To investigate the changes of serum levels of interleukin-33 (IL-33) and its receptor soluble growth STimulation expressed gene 2 (sST2) and monocyte chemotactic protein-1 (MCP-1) in patients with chronic hepatitis B virus infection, and to analyze their clinical significance. Methods One hundred and five patients with chronic hepatitis B virus infection in Dongguan People′s Hospital from January 2017 to January 2018 were selected as the observation group, including 67 patients with simple chronic hepatitis B (chronic hepatitis B group), 38 patients with hepatic failure (hepatic failure group), and 50 healthy volunteers without liver diseases were selected as the control group. Serum levels of IL-33, sST2 and MCP-1 were measured in each group, and the degree of hepatic fibrosis in chronic hepatitis B group was assessed according to Ishak pathological score. The expression of the above indicators in patients with different degrees of hepatic fibrosis was compared. Results The levels of IL-33, sST2 and MCP-1 in chronic hepatitis B group and hepatic failure group were significantly higher than those in control group, and the expression of IL-33, sST2 and MCP-1 in hepatic failure group was significantly higher than those in chronic hepatitis B group (P ＜ 0.05). Compared with mild hepatic fibrosis group, the levels of IL-33, sST2 and MCP-1 in moderate hepatic fibrosis group, severe hepatic fibrosis group and cirrhosis group increased, and the levels of IL-33, sST2 and MCP-1 in severe hepatic fibrosis group and cirrhosis group were higher than those in moderate hepatic fibrosis group, while the levels of IL-33, sST2 and MCP-1 in cirrhosis group were higher than those in severe hepatic fibrosis group, the differences were statistically significant (P ＜ 0.05). Pearson correlation analysis showed that IL-33, sST2 and MCP-1 was positively correlated with Ishak score in patients with chronic hepatitis B (r = 0.573, 0.728, 0.654, P ＜ 0.05). Conclusion Serum IL-33, sST2 and MCP-1 can evaluate and predict chronic hepatitis B virus infection and the aggravation of the disease. The test of serological indexes for the patients is helpful for disease diagnosis and prognosis evaluation.

Key words： Chronic hepatitis B virus Soluble growth STimulation expressed gene 2 Monocyte chemotactic protein-1 Interleukin-33

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	LI Jin1 LUO Zhongyu1 CHEN Liuzhen2 LIN Peiji1

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LI Jin1 LUO Zhongyu1 CHEN Liuzhen2 LIN Peiji1. Changes of serum IL-33, sST2 and MCP-1 levels in patients with chronic hepatitis B virus infection and its clinical significance[J]. 中国医药导报, 2019, 16(17): 125-128.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I17/125

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